Radiation dosimetry of the translocator protein ligands [18F]PBR111 and [18F]PBR102 Jordan D. Verschuer, Jocelyn Towson, Stefan Eberl, Andrew Katsifis,

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Radiation dosimetry of the translocator protein ligands [18F]PBR111 and [18F]PBR102 Jordan D. Verschuer, Jocelyn Towson, Stefan Eberl, Andrew Katsifis, David Henderson, Peter Lam, Lingfeng Wen, Christian Loc'h, Filomena Mattner, Sally Thomson, Armin Mohamed, Michael J. Fulham Nuclear Medicine and Biology Volume 39, Issue 5, Pages 742-753 (July 2012) DOI: 10.1016/j.nucmedbio.2011.11.003 Copyright © 2012 Terms and Conditions

Fig. 1 Single coronal slice of male baboon 111m injected with 147 MBq [18F]PBR111 (A) at 2 min pi shows tracer uptake in the lungs, heart wall and liver; there is tracer evident in the left upper limb vein ipsilateral to the site of injection. A zoomed in view of this slice (B) shows whole liver ROI defined at 2 min pi. The corresponding slice (C) at 15 min pi shows partial liver ROI within the right lobe of liver to avoid biliary tracer concentration. Nuclear Medicine and Biology 2012 39, 742-753DOI: (10.1016/j.nucmedbio.2011.11.003) Copyright © 2012 Terms and Conditions

Fig. 2 Coronal maximum intensity projections for (A) male baboon 111m injected with 147 MBq [18F]PBR111 and (B) female baboon 111f injected with 171 MBq [18F]PBR111 imaged from 2 min pi (left), 60 min pi (middle) and 120 min pi (right). Nuclear Medicine and Biology 2012 39, 742-753DOI: (10.1016/j.nucmedbio.2011.11.003) Copyright © 2012 Terms and Conditions

Fig. 3 Coronal maximum intensity projections for (A) male baboon 102m injected with 199 MBq [18F]PBR102 and (B) female baboon 102f injected with 176 MBq [18F]PBR102 imaged from 2 min pi (left), 60 min pi (middle) and 120 min pi (right). Nuclear Medicine and Biology 2012 39, 742-753DOI: (10.1016/j.nucmedbio.2011.11.003) Copyright © 2012 Terms and Conditions

Fig. 4 Decay-corrected TACs for [18F]PBR111 (A, B) and [18F]PBR102 (C, D), averaged for males and females. Nuclear Medicine and Biology 2012 39, 742-753DOI: (10.1016/j.nucmedbio.2011.11.003) Copyright © 2012 Terms and Conditions

Fig. 5 Decay-corrected TACs for [18F]PBR111 and [18F]PBR102 in gallbladder (A) and urinary bladder (B) for male and female baboons. Nuclear Medicine and Biology 2012 39, 742-753DOI: (10.1016/j.nucmedbio.2011.11.003) Copyright © 2012 Terms and Conditions