Volume 355, Issue 9222, Pages (June 2000)

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Volume 355, Issue 9222, Pages 2189-2193 (June 2000) Viral load of human papilloma virus 16 as a determinant for development of cervical carcinoma in situ: a nested case-control study Agnetha M Josefsson, PhD, Patrik KE Magnusson, PhD, Nathalie Ylitalo, MD, Per Sørensen, MSc, Pernilla Qwarforth-Tubbin, Prof Per Kragh Andersen, PhD, Prof Mads Melbye, MD, Prof Hans-Olov Adami, MD, Prof Ulf B Gyllensten, PhD The Lancet Volume 355, Issue 9222, Pages 2189-2193 (June 2000) DOI: 10.1016/S0140-6736(00)02401-6 Copyright © 2000 Elsevier Ltd Terms and Conditions

Figure 1 HPV 16 Ct values for case and control smears HPV 16 Ct values were separated into eight groups; mid-group values are shown. The Lancet 2000 355, 2189-2193DOI: (10.1016/S0140-6736(00)02401-6) Copyright © 2000 Elsevier Ltd Terms and Conditions

Figure 2 HPV 16 Ct values and distribution of β-actin Ct values for case and control smears by calendar year of preparation of smears The Lancet 2000 355, 2189-2193DOI: (10.1016/S0140-6736(00)02401-6) Copyright © 2000 Elsevier Ltd Terms and Conditions

Figure 3 Positive predictive value at different quintiles of distribution of HPV 16 Ct values Results presented are for women with a first smear diagnosed in 1970–74, but similar results were obtained for the other calendar periods. Categories of HPV 16 HPV 16 Ct values are as in table 3. Analyses are for smears with high amounts of nuclear DNA (⩾34·78 β-actin Ct). The Lancet 2000 355, 2189-2193DOI: (10.1016/S0140-6736(00)02401-6) Copyright © 2000 Elsevier Ltd Terms and Conditions