Interactive Workshop

HCV testing is Critical for early Diagnosis The goal is to increase early identification of (HCV) infection and increase access to care, and treatment. Testing is critical because so many people with HCV are unaware of their infection. (15). By testing and treating HCV patients we can save thousands of lives and decrease deaths from end stage liver disease and liver cancer. It is estimated that one-time testing of everyone born during 1945 through 1965 (US) will prevent more than 120,000 deaths.(6). HCV is treatable and curable, but we won't realize the potential of our therapy unless we identify those infected and provide them with care and treatment. (15).

HCV Treatment is Highly Curative New curative oral direct acting antivirals, whether monotherapy, combination therapy or polytherapy have shown increased SVR 8, 12, or 24 post treatment (16,17) Harvoni ION-3 Study GT 1 Tx naïve, VL <6 million IU/ml without cirrhosis SVR 97% GT 1 Tx naïve, VL >6 million IU/ml without cirrhosis SVR 96-99% GT 1 Tx exp, VL >6 million IU/ml without cirrhosis SVR 95% GT 1 Tx naïve, with cirrhosis SVR 94% GT 1 Tx exp, with cirrhosis SVR 97-100% GT 4,5,6 SVR 93-96%

HCV Treatment is Highly Curative Daklinza Ally 1 Study (18-19) GT 1 Advanced cirrhosis SVR 82% GT 3 Advanced cirrhosis SVR 83% GT 1, 3 Child-Pugh B SVR 91-93% GT 1, 3 Post Liver transplant SVR 95% GT 3, Tx naïve SVR 90% GT3, Tx exp SVR 86% GT 1, Co-infected HIV SVR 97% GT 3, Co-infected HIV SVR 100%

Interactive Workshop: Question HCV testing is critical for early diagnosis, and HCV treatment is highly curative. Many countries do not have access to treatment. Do you test HCV in settings with limited access to treatment? Why, Why not?? What barriers can be overcome? How can this effect patient outcome? What is the long term effect on the patient, the health care system? Ideas