by: Shima Mehrvar, Mette la Cour Advisor: Dr. Ranji

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Presentation transcript:

Assessment of Liver Tissue Metabolic State for Transplant using Optical Imaging by: Shima Mehrvar, Mette la Cour Advisor: Dr. Ranji Collaborator: Dr. Kim, Dr. Hong, and Dr. Camara

Introduction Motivation Aim Only 72 % of people who get liver transplant survive after 3 years. Blood assays does not provide enough functional information about the liver tissue for transplantation. Metabolic state is an important key marker for hepatic functionality. Aim To quantify the metabolic state of livers before, during and after transplant using optical imaging technique.

Method Sample Preparation Control Ischemia Reperfusion

Method Cryo imager 3D images Mitochondrial autofluorescence signals: NADH and FAD Redox Ratio (RR) = NADH/FAD Metabolic quantitative marker

Results Optical images

Results *

Future Direction Cryoimager Fluorometry Can be translated to biopsies from human liver Further assessment of Ischemia reperfusion injury Fluorometry Ex vivo or in vivo probing autofluorescence signals for clinical applications

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