Chapter 19: The Cell Cycle.

Slides:



Advertisements
Similar presentations
Regulators of Cell Cycle Progression (Literature Review) Prepared by Cai Chunhui.
Advertisements

THE BIOLOGY OF CANCER A group of diseases identified by uncontrolled cell growth and proliferation VirusesGenetic make-upImmune statusRadiationCarcinogens.
4/12/2015 The Cell Cycle Control “to divide or not to divide, that is the question”.
Biology of cultured cells conti- Part 4 By : Saib al owini.
Cells must either reproduce or they die. Cells that can not reproduce and are destined to die are terminal cells (red blood, nerve cells, muscles cells.
Cell and Molecular Biology Behrouz Mahmoudi Cell cycle 1.
AP Biology Regulation of Cell Division.
Escherichia coli – LPS/O antigens, OMPs, flagella, peptidoglycan, inner membrane, DNA, ribosomes, tRNA, various protein assemblies.
Mitosis n Mitosis is the process by which new cells are generated. n Mitosis produces 2 genetically identical daughter cells.
Mitosis, Meiosis, Cell Cycle Control, Cyclin, Checkpoints, Cyclin-Dependent kinase, External and Internal WHAT THEY ARE!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!!
The Cell Cycle Chapter 12. Mitosis  Cell division  Produce 2 daughter cells  Same genetic information.
Chapter 23 – Cancer Genetics. Tumor Mass of abnormally dividing cells –Normal cells exhibit contact inhibition in culture Benign –Usually well-defined.
Cyclins G1 cyclin (cyclin D) S-phase cyclins (cyclins E and A) mitotic cyclins (cyclins B and A) Cyclin-dependent kinases (Cdks)kinases G1 Cdk (Cdk4) S-phase.
Chapter 12 The Cell Cycle.
1 hr hr 8 hr 4-6 hr (M) Spindle-assembly checkpoint - confirms that all the chromosomes are properly attached to the spindles. Resting phase (G0)
The Cell Cycle. Overview What are the various stages of the cell cycle? What are the various stages of the cell cycle?
Cell & Molecular Biology Control of the Cell Cycle.
e/animations/hires/a_cancer5_h.html
CHAPTER 14 Cellular Reproduction. Introduction Cells reproduce by the process of cell division. Mitosis leads to cells that are genetically identical.
Regulation of the Cell Cycle In Most Animals. Cell Cycle Checkpoints The decision to proceed from one part of the cell cycle to another depends on a variety.
Cell Cycle Control System
Chapter 12 The Cell Cycle. Rudolf Virchow-1855 “Omnis cellula e cellula” Every cell from a cell. In this chapter we will learn how cells reproduce to.
You are performing mitosis. Where is this occurring? Describe what is happening.
Chapter 12: The Cell Cycle
Ch 12 Mitosis and The Cell Cycle. The Cell Cycle 1.What is it and why does it exist? -The timing and rate of cell division is crucial to normal growth.
CELL CYCLE.
G2 Checkpoint 1.Controls entry to mitosis 2. DNA replication assessed 3. Full genome must be present to allow copy for each daughter cell M-checkpoint.
Regulation of Cell Division Coordination of cell division A multicellular organism needs to coordinate cell division across different tissues & organs.
You are performing mitosis. Where is this occurring? Describe what is happening.
Cell Cycle Checkpoint.
Cell Cycle Regulation. The Cell Cycle What can be learned from this experiment? There are different signals (proteins) present that aid in the progression.
Raven & Johnson Chapter 10 Campbell Chapter 12 THE CELL CYCLE.
Cell Division. Paired “threads” Figure 8.1 An Early View of Mitosis.
HOW DO CHECKPOINTS WORK? Checkpoints are governed by phosphorylation activity controlled by CDK’s (cyclin dependent kinases) Checkpoints are governed.
Cell Cycle Control and Cancer What happens when things go wrong?
 The timing and rate of cell division is crucial to normal growth, development, and maintenance of multicellular organisms.
G1 G2 M S Is DNA damaged? Is DNA replication complete? Is the mitotic spindle assembled? Are chromosomes properly segregated? adapted from: Alberts et.
The Cell Cycle and Cancer. How is growth controlled? How is the Cell Cycle Regulated? Clue: cytoplasmic chemicals can signal mitosis.
The Cell Cycle October 12, Cell Division Functions in Reproduction, Growth, and Repair.
CHAPTER 12  THE CELL CYCLE I. The key roles of cell division A. Reproduction 1. Prokaryotic 2. Eukaryotic a. Plants & some animals B. Development 1. Zygote.
The Cell Cycle Chapter 12. Objectives Understand the need for cell division Understand the process of mitosis and cytokinesis Know the parts of each phase.
Cell Cycle Regulation Chapter – Pt. 1 Pgs Objective: I can describe and how the cell cycle is regulated and controlled to occur at certain.
 Chapter 12~ The Cell Cycle. 3 Key Roles of Cell Division  Reproduction  Growth and development  Tissue renewal and repair.
Cell cycle 김다은 성균관대학교 / 약학과
Controlling a Cell’s Progress through the Cell Cycle
Cell Division.
Cell Division Prokaryotic binary fission sporulation Eukaryotic
The Cell Cycle Chapter 12 Unit 4.
Chapter 12: The Cell Cycle
Controlling a Cell’s Progress through the Cell Cycle
Question of the Day What is the correct phase of the cell cycle/mitosis for the following: Most cells that no longer divide or rarely divide are in this.
Chapter 12~ The Cell Cycle
Regulation of the Cell Cycle & Cancer
Regulation of DNA Replication
Chap. 19 Problem 1 Passage through the cell cycle is unidirectional and irreversible due to the degradation of critical regulators by proteasome complexes.
Summary of Cell Cycle and its Regulation
Cell Cycle & Checkpoints
Chapter 12: The Cell Cycle
Regulation of the Cell Cycle
Chapter 12: The Cell Cycle
Chapter 12: The Cell Cycle
How Do Cells Divide?.
Heterodimeric Protein Kinases
MITOSIS Nuclear Cell Division.
The cell cycle: The continuity of life depends on cells growing, replicating their genetic material, and then dividing. The cell cycle consists of two.
MODIFIED from a slide show by Kim Foglia
Cell Cycle Regulation Learning Activities
Chapter 12: The Cell Cycle
Control of the Cell Cycle
Chapter 12: The Cell Cycle
Presentation transcript:

Chapter 19: The Cell Cycle

The Cell Cycle

The Cell Cycle Control System

Cell Cycle Control Molecules Cyclin-Dependent Kinases (Cdks) Maturation promotion factor (MPF) Anaphase-promoting complex (APC) Rb Protein

Cdks Remember: Phosphorylation/dephosphorylation are commonly used for regulation of protein (enzyme) activity Cdks: kinases that are only active when bound to a protein from the cyclin family Several dozen cyclins have been discovered Their concentrations within a cell increase and decrease throughout the cell cycle

Cyclins Wikipedia.org image

Cell Cycle Control Molecules Cyclin-Dependent Kinases (Cdks) Maturation promotion factor (MPF) Anaphase-promoting complex (APC) Rb Protein

Evidence for Existence of MPF

MPF Regulation

MPF Levels Fluctuate During the Cell Cycle

Cell Cycle Control Molecules Cyclin-Dependent Kinases (Cdks) Maturation promotion factor (MPF) Anaphase-promoting complex (APC) Rb Protein

Anaphase-Promoting Complex

Cell Cycle Control Molecules Cyclin-Dependent Kinases (Cdks) Maturation promotion factor (MPF) Anaphase-promoting complex (APC) Rb Protein

Rb Protein

Cell Cycle Checkpoints Mitotic spindle checkpoint DNA Replication checkpoint DNA Damage checkpoint

Mitotic Spindle Checkpoint

Cell Cycle Checkpoints Mitotic spindle checkpoint DNA Replication checkpoint DNA Damage checkpoint

DNA Damage Checkpoint

Putting it all together!

Putting it all together!

Feedback: Privacy Policy Feedback
Do Not Sell My Personal Information
About project: SlidePlayer Terms of Service

© 2025 SlidePlayer.com. Inc. All rights reserved.