Enhanced angiogenesis and growth of collaterals by in vivo administration of recombinant basic fibroblast growth factor in a rabbit model of acute lower.

Slides:

Advertisements

Similar presentations

Timing of carotid endarterectomy after acute stroke Joseph J. Plotrowski, MD, Victor M. Bernhard, MD, Jeffrey R. Rubin, MD, Kenneth E. McIntyre, MD, James.

Advertisements

Endothelial cell seeding reduces thrombogenicity of Dacron grafts in humans Per Örtenwall, MD, PhD *, Hans Wadenvik, MD, PhD **, Jack Kutti, MD, PhD **,

The role of arteriovenous shunts in the pathogenesis of varicose veins Howard C. Baron, M.D., Sebastiano Cassaro, M.D. Journal of Vascular Surgery Volume.

The effect of inguinal lymphatic manipulation on regional lymph flow patterns Jeffrey R. Rubin, MD, Lisa B. Eberlin, MD Journal of Vascular Surgery Volume.

Popliteal artery stenosis caused by a Baker's cyst

Clinical evaluation of recombinant human platelet – derived growth factor for the treatment of lower extremity diabetic ulcers David L. Steed, MD, the.

Is long vein bypass from groin to ankle a durable procedure

Aortic injury occurring after minor trauma in ankylosing spondylitis

Heparin-coated catheters and heparin-induced thrombocytopenia

Safety and efficacy of femoral-based hemodialysis access grafts

Regulation of new blood vessel growth into ischemic skeletal muscle

Mycotic axillary artery aneurysm

A new valvulotome for in situ bypass grafts

Aortic injury occurring after minor trauma in ankylosing spondylitis

Jeffrey R. Rubin, M.D., James M. Malone, M.D., Jerry Goldstone, M.D.

Intra-arterial streptokinase therapy to relieve acute limb ischemia

Relationship of severity of lower limb peripheral vascular disease to mortality and morbidity: A six-year follow-up study Mary A. Howell, MD, Mary Paula.

Malcolm O. Perry, MD, Richard Kempczinski, MD

Recurrent thoracic outlet syndrome

Extracranial carotid aneurysms: Report of six cases and review of the literature Thomas A. Painter, M.D., Norman R. Hertzer, M.D., Edwin G. Beven, M.D.,

Heparin-coated catheters and heparin-induced thrombocytopenia

Minimal physiologic temperature variations during renal ischemia alter functional and morphologic outcome Timothy J. Pelkey, BS, Richard S. Frank, MD,

Protection of the kidney after temporary ischemia: Free radical scavengers Kenneth Ouriel, M.D., Nicholas G. Smedira, M.D. *, John J. Ricotta, M.D. Journal.

Ex vivo gene delivery of ephrin-B2 induces development of functional collateral vessels in a rabbit model of hind limb ischemia Masatake Katsu, MD, Hiroyuki.

Reduction of hospital resources utilization in vascular surgery: A four-year experience Sean P. Roddy, MD, Thomas F. O'Donnell, MD, Mark D. Iafrati, MD,

Objective tinnitus resulting from internal carotid artery stenosis

Controlled delivery of vascular endothelial growth factor promotes neovascularization and maintains limb function in a rabbit model of ischemia Steven.

Ramyar Gilani, MD, Roy K. Greenberg, MD, Douglas R. Johnston, MD

Dhiraj M. Shah, MD, Benjamin B. Chang, MD, Philip S. K

William C. Pevec, MD, Douglas Hendricks, MD, Marc S

Lower extremity ischemia in adults younger than forty years of age: A community-wide survey of premature atherosclerotic arterial disease Pavel J. Levy,

Calvin B. Ernst, MD Journal of Vascular Surgery

An improved retraction system for vascular surgical procedures

John Hunter—triumph and tragedy

Carotid endarterectomy and local intraarterial thrombolysis: Simultaneous procedure in acute occlusion of the internal carotid artery and middle cerebral.

Ankle and foot fasciotomy: An adjunctive technique to optimize limb salvage after revascularization for acute ischemia Enrico Ascer, MD, Berish Strauch,

Cardiovascular surgery—The rocket and its stars: Presidential address

The role of a defined protocol for cardiac risk assessment in decreasing perioperative myocardial infarction in vascular surgery T.J. Bunt, MD Journal.

Peter F. Lawrence, MD, Ke Li, MD, Steven W. Merrell, MD, Greg R

Composite sequential bypasses to the ankle and beyond for limb salvage

Research and research funding in vascular surgery

J.Dennis Baker, MD Journal of Vascular Surgery

James E. Edwards, MD, Lloyd M. Taylor, MD, John M. Porter, MD

Septic embolism complicating infective endocarditis

Arie Markel, MD, Richard A. Manzo, BS, CCVT, Robert O. Bergelin, MS, D

Avoiding reperfusion injury after limb revascularization: Experimental observations and recommendations for clinical application Friedhelm Beyersdorf,

Surgical management of severe acute lower extremity ischemia

Seizures following subclavian-carotid bypass

Early experience with cryopreserved saphenous vein allografts as a conduit for complex limb-salvage procedures Philip J. Walker, FRACS, R.Scott Mitchell,

Jay B. Fisher, MD, Marc A. Granson, MD Journal of Vascular Surgery

Richard J. Sanders, MD 1, William H. Pearce, MD 2

Evaluation of a proposed standard reporting system for preoperative angiograms in infrainguinal bypass procedures: Angiographic correlates of measured.

Acute aortic occlusion – Factors that influence outcome

Ronald L. Dalman, MD, Lloyd M. Taylor, MD, Gregory L

Exposure of femoral vessels by a suprainguinal incision

Monitoring vascular surgical performance

William E. Evans, M.D., James P. Hayes, M.S.

Aortoesophageal fistula: Case report and literature review

D. Emerick Szilagyi, MD—An appreciation

Presidential address: The second-generation vascular surgeon

Richard F. Kempczinski, M.D. Journal of Vascular Surgery

George D. Lilly 1906–1988 Journal of Vascular Surgery

James A. DeWeese, MD Journal of Vascular Surgery

Left subclavian artery aneurysm: Two cases of rare congenital etiology

Femur fracture with limb shortening causing occlusion of a polytetrafluoroethylene femoral popliteal graft Joshua I. Ellenhorn, MD, Richard J. Fowl,

Vascular applications of telepresence surgery: Initial feasibility studies in swine Jon C. Bowersox, MD, PhD, Ajit Shah, PhD, Joel Jensen, MS, John Hill,

Lower extremity lymphedema caused by acquired immune deficiency syndrome – related Kaposi's sarcoma: Case report and review of the literature Peter J.

Thigh claudication due to profunda femoris artery occlusion

Prevention of stenosis after vascular reconstruction: Pharmacologic control of intimal hyperplasia—A review Alexander W. Clowes, MD, Michael A. Reidy,

Endovascular repair of two abdominal aortic aneurysms

Presentation transcript:

Enhanced angiogenesis and growth of collaterals by in vivo administration of recombinant basic fibroblast growth factor in a rabbit model of acute lower limb ischemia: Dose-response effect of basic fibroblast growth factor Richard Baffour, PhD, Joel Berman, MD, Jane L. Garb, MS, Sang Won Rhee, MD, Jeffrey Kaufman, MD, Paul Friedmann, MD Journal of Vascular Surgery Volume 16, Issue 2, Pages 181-191 (August 1992) DOI: 10.1016/0741-5214(92)90106-I Copyright © 1992 Society for Vascular Surgery and the North American Chapter, International Society for Cardiovascular Surgery Terms and Conditions

Fig. 1 Surgical procedure is shown; second stage is performed 1 week later. Journal of Vascular Surgery 1992 16, 181-191DOI: (10.1016/0741-5214(92)90106-I) Copyright © 1992 Society for Vascular Surgery and the North American Chapter, International Society for Cardiovascular Surgery Terms and Conditions

Fig. 2 Experimental protocol. Journal of Vascular Surgery 1992 16, 181-191DOI: (10.1016/0741-5214(92)90106-I) Copyright © 1992 Society for Vascular Surgery and the North American Chapter, International Society for Cardiovascular Surgery Terms and Conditions

Fig. 3 Representative angiograms; Angiographic evidence of revascularization by exogenous bFGF are compared. A, saline control; B, 1 μg bFGF; C, 3 μg bFGF animals. Journal of Vascular Surgery 1992 16, 181-191DOI: (10.1016/0741-5214(92)90106-I) Copyright © 1992 Society for Vascular Surgery and the North American Chapter, International Society for Cardiovascular Surgery Terms and Conditions

Fig. 4 Comparison of treatment groups on TcPo2 measurements on days 1, 7, and 14. Journal of Vascular Surgery 1992 16, 181-191DOI: (10.1016/0741-5214(92)90106-I) Copyright © 1992 Society for Vascular Surgery and the North American Chapter, International Society for Cardiovascular Surgery Terms and Conditions

Fig. 5 Representative histologic sections; Left thigh; vastus medialis muscle sections histochemically stained for alkaline phosphatase activity. Dark spots represent capillaries. (A) saline control (× 250); (B) 1 μg bFGF (× 250); (C) 3 μg bFGF (× 250). Journal of Vascular Surgery 1992 16, 181-191DOI: (10.1016/0741-5214(92)90106-I) Copyright © 1992 Society for Vascular Surgery and the North American Chapter, International Society for Cardiovascular Surgery Terms and Conditions

Fig. 6 Comparison of treatment groups on muscle TTC reduction. Journal of Vascular Surgery 1992 16, 181-191DOI: (10.1016/0741-5214(92)90106-I) Copyright © 1992 Society for Vascular Surgery and the North American Chapter, International Society for Cardiovascular Surgery Terms and Conditions