In Situ Measurement of Solvent-Mediated Phase Transformations During Dissolution Testing Jaakko Aaltonen, Paula Heinänen, Leena Peltonen, Hanna Kortejärvi,

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Presentation transcript:

In Situ Measurement of Solvent-Mediated Phase Transformations During Dissolution Testing Jaakko Aaltonen, Paula Heinänen, Leena Peltonen, Hanna Kortejärvi, Veli Pekka Tanninen, Leena Christiansen, Jouni Hirvonen, Jouko Yliruusi, Jukka Rantanen Journal of Pharmaceutical Sciences Volume 95, Issue 12, Pages 2730-2737 (December 2006) DOI: 10.1002/jps.20725 Copyright © 2006 Wiley-Liss, Inc., A Wiley Company Terms and Conditions

Figure 1 The experimental sets-up. (a) Raman probe assembly and (b) the channel flow dissolution apparatus. Journal of Pharmaceutical Sciences 2006 95, 2730-2737DOI: (10.1002/jps.20725) Copyright © 2006 Wiley-Liss, Inc., A Wiley Company Terms and Conditions

Figure 2 Results of the dissolution test of TP anhydrate. For comparison, dashed line shows constant dissolution rate from a compact prepared of TP monohydrate. Journal of Pharmaceutical Sciences 2006 95, 2730-2737DOI: (10.1002/jps.20725) Copyright © 2006 Wiley-Liss, Inc., A Wiley Company Terms and Conditions

Figure 3 SEM micrographs of solvent-mediated phase transformation on the surface of a compact prepared of TP anhydrate. Compact surface (a) before, (b) after 2-min, (c) after 6-min exposure to water. Journal of Pharmaceutical Sciences 2006 95, 2730-2737DOI: (10.1002/jps.20725) Copyright © 2006 Wiley-Liss, Inc., A Wiley Company Terms and Conditions

Figure 4 The results of the dissolution test of a compact prepared of 1:1 powder mixture of TP anhydrate and MCC. Journal of Pharmaceutical Sciences 2006 95, 2730-2737DOI: (10.1002/jps.20725) Copyright © 2006 Wiley-Liss, Inc., A Wiley Company Terms and Conditions

Figure 5 The results of the dissolution test of NF anhydrate. (a) Solid-state transformation, (b) and (c) concentration of the dissolution medium (different time scales). Journal of Pharmaceutical Sciences 2006 95, 2730-2737DOI: (10.1002/jps.20725) Copyright © 2006 Wiley-Liss, Inc., A Wiley Company Terms and Conditions

Figure 6 SEM micrographs of solvent-mediated phase transformation on the surface of a compact prepared of NF anhydrate. Compact surface (a) after 10-min, (b) after 30-min, (c) after 1150-min exposure to water. Journal of Pharmaceutical Sciences 2006 95, 2730-2737DOI: (10.1002/jps.20725) Copyright © 2006 Wiley-Liss, Inc., A Wiley Company Terms and Conditions