Coconut Oil and Improvement in Alzheimer’s Disease Rachel Lowry http://www.ohsu.edu/blogs/brain/2013/06/26/the-continuing-search-for-the-answer-to-alzheimers-disease/ Organiclifestylemagazine.com

Overview Background Study 1 Study 2 Conclusion

Coconut Oil Sat. fat = 92% MCTs=67-70% Medium Chain Triglycerides (MCTs) Ketones Population health www.dreamstime.com

Alzheimer’s 5.4 million Americans (2012) Gradual accumulation of amyloid-β(Aβ) and intracellular neurofibrillary tangles. 17-20 years before disease is noticed Diet could play important role http://www.americannursetoday.com/easing-the-anguish-of-alzheimers-disease/

Coconut Oil + Alzheimer’s (Extra) Virgin Coconut Oil Do not re-heat Glucose utilization is impaired in AD Ketones can replace glucose as brain’s energy source https://sites.psu.edu/siowfa15/2015/10/08/alzheimers-disease/

Study 1 Prevention of amyloid-βbuild-up in brain T2DM and CVD Ketones can cross the blood-brain barrier easily Caprylic acid and lauric acid http://www.healthline.com/health-slideshow/alzheimers-coconut-oil

Caprylic & Lauric Acids

Study 2: The Newports Dr. Newport claims she cured husband of AD with coconut oil Many factors such as exercise, healthy diet, and many other supplements.

Study 2, cont’d Axona ® is FDA approved (2009) Reger et al. (2004) found β-hydroxybutyrate most helpful Krikorian (2012) found improvement in MCI subjects with a ketogenic diet http://www.bodybuilding.com/fun/the-surprising-truth-about-coconut-oil.html http://theadplan.com/alzheimersdietblog/axona/the-exciting-new-news-about-medical-foods/attachment/axona-image/

Conclusion Though coconut oil is a saturated fatty acid, it does not show the negative side effects of other SFAs. Axona ® and anticholinesterase medications Do not reheat coconut oil Not for T2DM or liver problems Need more research!!! https://www.eheandme.com/news_articles/549644810

References Fernando, W. M. A. D. B., Martin, I. J., Goozee, K. G., Brennan, C. S., Jayasena, V., Martins, R. N. (2015). The role of dietary coconut for the prevention and treatment of Alzheimer’s disease: Potential mechanisms of action. British Journal of Nutrition 114, 1-14. doi:10.1017/S0007114515001452 Doty, L. (2012). Coconut oil for Alzheimer’s disease? Clinical Practice 1(2), 12-17. doi:10.5923/j.cp.20120102.01 Reger, M. A., Henderson, S.T., Hale, C., Cholerton, B., Baker, L.D., Watson ,G.S., et al. (2004). Effects of beta-hydroxybutyrate on cognition in memory-impaired adults. Neurobiological Aging 25(3), 311-314. Krikorian, R., Shidler, M.D., Dangelo, K., Couch, S.C., Benoit, S.C., Clegg. D.J. (2012) Dietary ketosis enhances memory in mild cognitive impairment. Neurobiological Aging 33(2) 425.e19-27.