Effect of abciximab-coated stent on in-stent intimal hyperplasia in human coronary arteries Young Joon Hong, MD, Myung Ho Jeong, MD, PhD, Weon Kim, MD,

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Effect of abciximab-coated stent on in-stent intimal hyperplasia in human coronary arteries Young Joon Hong, MD, Myung Ho Jeong, MD, PhD, Weon Kim, MD, Sang Yup Lim, MD, Sang Hyun Lee, MD, Seo Na Hong, MD, Ju Han Kim, MD, Young Keun Ahn, MD, Jeong Gwan Cho, MD, PhD, Jong Chun Park, MD, PhD, Dong Lyun Cho, PhD, Hoon Kim, MS, Jung Chaee Kang, MD, PhD American Journal of Cardiology Volume 94, Issue 8, Pages 1050-1054 (October 2004) DOI: 10.1016/j.amjcard.2004.06.066 Copyright © 2004 Excerpta Medica Inc. Terms and Conditions

FIGURE 1 Scanning electron microscopic findings after abciximab coating on the surface of the stent. American Journal of Cardiology 2004 94, 1050-1054DOI: (10.1016/j.amjcard.2004.06.066) Copyright © 2004 Excerpta Medica Inc. Terms and Conditions

FIGURE 2 Scanningelectron microscopic findings of abciximab grafting after washing test: stent surface with abciximab grafting immediately (upper left panel), 5 hours (upper right panel), 2 weeks (middle left panel), and 4 weeks (middle right panel) after washing test (magnification 250 ×); cross section of the stent with abciximab grafting immediately (lower left panel) and 1 month (lower right panel) after washing test (magnification 30,000 ×). American Journal of Cardiology 2004 94, 1050-1054DOI: (10.1016/j.amjcard.2004.06.066) Copyright © 2004 Excerpta Medica Inc. Terms and Conditions

FIGURE 3 In vitro screening of abciximab release from stent surface. Insert, the linear relation between ultraviolet absorbance at 278 nm and the concentration of abciximab in water. American Journal of Cardiology 2004 94, 1050-1054DOI: (10.1016/j.amjcard.2004.06.066) Copyright © 2004 Excerpta Medica Inc. Terms and Conditions

FIGURE 4 Coronaryangiography and IVUS showed critical stenosis in the proximal right coronary artery, with abundant atheromatous plaque within the lesion before stenting (A). After successful abciximab-coated stent placement, the coronary artery had good patency, without residual stenosis (B). At 6-month follow-up coronary angiography and IVUS, no ISR in the previously stented right coronary artery was observed (C). American Journal of Cardiology 2004 94, 1050-1054DOI: (10.1016/j.amjcard.2004.06.066) Copyright © 2004 Excerpta Medica Inc. Terms and Conditions