C Supplemental Figure S2.. C Supplemental Figure S2.

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C Supplemental Figure S2.

Supplemental Figure S4. RhoGDI2 mRNA expression levels were assessed in breast tumors (all subtypes) using publically available breast cancer expression array datasets and Km Plotter software (kmplot.org). Affymetrix probe 1555812_a_at (ARHGDIB/RhoGDI2) in breast cancer samples (N = 1660) was used. Samples were separated at the median level RhoGDI2/ARHGDIB expression, and plotted against metastasis-free survival for each sample in the shown Kaplan-Meier curve.

Supplemental Figure S5. TIAM1 mRNA expression levels were assessed in breast tumors (all subtypes) using publicly available breast cancer expression array datasets and cBio software (cbio.org). The METABRIC data set (N = 2509) was used. Samples with TIAM1 expression > 1.5 S.D. from the mean for all tumors in the group, combined with tumors gene amplified for TIAM1 (for a total of 6% of the 2509 tumors) were plotted against overall survival for each sample in the shown Kaplan-Meier curve. Log-rank test for statistical significance was calculated by cBio software.

Number of cells migrating P = n.s. P < 0.001 Number of cells migrating Supplemental Figure S6. SKBR3 cells expressing shScr or shRictor were transduced with Ad.RFP or with Ad.AktDD. Cells were seeded in the upper chambers of transwell inserts, and the number of cells reaching the bottom side of the insert was measured on crystal violet-stained filters 24 h after seeding. Student’s T-test was used to assess significance. N = 4.