Copyright © 2005 American Medical Association. All rights reserved.

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Copyright © 2005 American Medical Association. All rights reserved. From: Bystander Modulation of Chemokine Receptor Expression on Peripheral Blood T Lymphocytes Mediated by Glatiramer Therapy Arch Neurol. 2005;62(6):889-894. doi:10.1001/archneur.62.6.889 Figure Legend: Interferon γ (IFN-γ) (TH1)/interleukin 5 (IL-5) (TH2) cytokine ratios on glatiramer acetate–specific (A), myelin basic protein–specific (MBP) (B), and tetanus toxoid (TT)–specific (C) T cells at visit 1 (V1) (baseline, before glatiramer therapy) and visit 2 (V2) (12 months after initiation of glatiramer therapy). A total of 372 (122 glatiramer, 122 MBP, and 128 TT) T-cell lines were examined (see the “Methods” section). Horizontal bars represent median ratios. Significant decreases in the ratio were determined using Mann-Whitney U tests (nonparametric data). Date of download: 10/17/2017 Copyright © 2005 American Medical Association. All rights reserved.

Copyright © 2005 American Medical Association. All rights reserved. From: Bystander Modulation of Chemokine Receptor Expression on Peripheral Blood T Lymphocytes Mediated by Glatiramer Therapy Arch Neurol. 2005;62(6):889-894. doi:10.1001/archneur.62.6.889 Figure Legend: Mean chemokine receptor (CKR) expression on CD4+ and CD8+ subsets of antigen-specific T-cell lines (TCLs) at visit 1 (V1) and visit 2 (V2) as determined using flow cytometric analysis of TCLs (see the “Methods” section). The CKRs on glatiramer acetate–reactive TCLs are shown in CXCR3 (A), CCR7 (B), CXCR6 (C), CCR5 (D), and CCR4 (E). The CXCR3 expression on glatiramer TCLs compared with myelin basic protein (MBP)– and tetanus toxoid (TT)–specific TCLs is also shown (F). Two-tailed unpaired t tests (parametric data) were used to measure significant differences between CKR expression at V1 vs V2. Asterisk indicates P < .001; error bars, SEM. Date of download: 10/17/2017 Copyright © 2005 American Medical Association. All rights reserved.

Copyright © 2005 American Medical Association. All rights reserved. From: Bystander Modulation of Chemokine Receptor Expression on Peripheral Blood T Lymphocytes Mediated by Glatiramer Therapy Arch Neurol. 2005;62(6):889-894. doi:10.1001/archneur.62.6.889 Figure Legend: Serial analysis of mean CXCR3 (A) and CCR7 (B) (chemokine receptors) expression on CD4+ glatiramer acetate–specific T-cell lines at baseline (month 0) and at months 6, 12, and 16 after initiation of glatiramer therapy. Significant differences were determined using 1-way analysis of variance (ANOVA), and posttest analysis of change from baseline was made using the Dunnett multiple comparison test. Error bars represent SEM. Date of download: 10/17/2017 Copyright © 2005 American Medical Association. All rights reserved.

Copyright © 2005 American Medical Association. All rights reserved. From: Bystander Modulation of Chemokine Receptor Expression on Peripheral Blood T Lymphocytes Mediated by Glatiramer Therapy Arch Neurol. 2005;62(6):889-894. doi:10.1001/archneur.62.6.889 Figure Legend: Migration of glatiramer acetate–reactive T-cell lines in response to CCL19 (CCR7 ligand), CXCL-10 (CXCR3 ligand), and RANTES (regulated upon activation, normal T-cell expressed and secreted) (CCR5 ligand). Glatiramer T-cell lines established from patients before glatiramer therapy (visit 1) or after 12 months of glatiramer therapy (visit 2) were stimulated for 48 hours with plate-bound αCD3 (1 μg/mL) plus soluble αCD28 (1 μg/mL) and then were incubated in Transwell chambers for 3 hours. The number of T cells migrating across 5-μm pore filters into lower chambers containing 500 ng/mL indicated chemokines and was quantified and expressed as the migration index (see the “Methods” section). Two-tailed unpaired t tests (parametric data) were used to measure significant differences in migration with and without chemokine. Asterisk indicates P < .01; dagger, P < .05. Error bars represent the SE of triplicate wells. Date of download: 10/17/2017 Copyright © 2005 American Medical Association. All rights reserved.

Copyright © 2005 American Medical Association. All rights reserved. From: Bystander Modulation of Chemokine Receptor Expression on Peripheral Blood T Lymphocytes Mediated by Glatiramer Therapy Arch Neurol. 2005;62(6):889-894. doi:10.1001/archneur.62.6.889 Figure Legend: Mean percentage of CD4+ or CD8+ glatiramer acetate–reactive T cells as measured by flow cytometry at visit 1 (V1) (baseline, before glatiramer therapy) and visit 2 (V2) (12 months after initiation of glatiramer therapy). Stimulation indices (SIs) of glatiramer-reactive T-cell lines at V1 and V2 are also shown. Two-tailed unpaired t tests (parametric data) were used to measure significant differences between surface expression and SIs at V1 vs V2. Asterisk indicates P < .001; error bars, SEM. Date of download: 10/17/2017 Copyright © 2005 American Medical Association. All rights reserved.

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