Rotavirus vaccines: Successes and challenges

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Rotavirus vaccine impact. Introduction. Rotavirus vaccines lead to significant reductions in severe and fatal diarrhea in both vaccinated and unvaccinated.

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Rotavirus vaccines: Successes and challenges Roger I. Glass, Umesh Parashar, Manish Patel, Jon Gentsch, Baoming Jiang Journal of Infection Volume 68, Pages S9-S18 (January 2014) DOI: 10.1016/j.jinf.2013.09.010 Copyright © 2013 Terms and Conditions

Figure 1 Electron micrograph of rotavirus particles in stool of a child with rotavirus diarrhea (Marker represents 100 microns). Journal of Infection 2014 68, S9-S18DOI: (10.1016/j.jinf.2013.09.010) Copyright © 2013 Terms and Conditions

Figure 2 National rotavirus vaccine introductions by geographic region: 47 countries shown. ∗Courtesy of PATH at: http://sites.path.org/rotavirusvaccine/rotavirus-advocacy-and-communications-toolkit/country-introduction-maps-and-list/. Journal of Infection 2014 68, S9-S18DOI: (10.1016/j.jinf.2013.09.010) Copyright © 2013 Terms and Conditions

Figure 3 Distribution of global rotavirus mortality, 2008. *From Ref. 36 [author's (UDP) own data]. Journal of Infection 2014 68, S9-S18DOI: (10.1016/j.jinf.2013.09.010) Copyright © 2013 Terms and Conditions

Figure 4 Direct and indirect benefits of vaccine as evidenced by reduction in severe rotavirus diarrhea among vaccinated and unvaccinated children after the introduction of a rotavirus vaccine in various countries. *Adapted from Table 4, Ref. 5. Journal of Infection 2014 68, S9-S18DOI: (10.1016/j.jinf.2013.09.010) Copyright © 2013 Terms and Conditions

Figure 5 Decline in diarrhea deaths among children under 5 after the introduction of rotavirus vaccine in Mexico in 2007. *From Ref. 53 [authors' own (MMP, UDP) data]. Journal of Infection 2014 68, S9-S18DOI: (10.1016/j.jinf.2013.09.010) Copyright © 2013 Terms and Conditions

Figure 6 Factors suspected to interfere with “take” of oral rotavirus vaccine in low-income settings. *Adapted from Ref. 47. Journal of Infection 2014 68, S9-S18DOI: (10.1016/j.jinf.2013.09.010) Copyright © 2013 Terms and Conditions