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From: Combined PI3K/Akt and Smad2 Activation Promotes Corneal Endothelial Cell Proliferation Invest. Ophthalmol. Vis. Sci.. 2017;58(2):745-754. doi:10.1167/iovs.16-20817 Figure Legend: Stem cell and neural crest stem cell marker expression levels in growing rabbit and primate CEC. Immunofluorescence staining showed expression of stem cell markers OCT4 (A, E), NANOG (B, F), and SOX2 (C, G) and neural crest stem cell marker p75NTR (D, H) in rabbit and primate nonconfluent (A–H) CEC. Stem cell marker OCT4 showed its characteristic nuclear staining. NANOG and SOX2 exhibited a combined nuclear and cytoplasmic staining. Expression of stem cell markers OCT4 (I, M), NANOG (J, N), and SOX2 (K, O) and neural crest stem cell marker p75NTR (L, P) was negative in rabbit and primate confluent (I–P) CEC. SOX2 cytoplasmic expression was positive in some rabbit CEC at confluence. Date of download: 10/17/2017 The Association for Research in Vision and Ophthalmology Copyright © 2017. All rights reserved.