Calculations for contributions of Ca2+ influx through three types of voltage-independent Ca2+ channels to ET-1-induced EGFR PTK transactivation in VSMCs.

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Calculations for contributions of Ca2+ influx through three types of voltage-independent Ca2+ channels to ET-1-induced EGFR PTK transactivation in VSMCs. A, B: ET-1-induced EGFR PTK phosphorylation in the presence of 10 μM LOE-908 or 10 μM SK&F-96365 is rep... Calculations for contributions of Ca2+ influx through three types of voltage-independent Ca2+ channels to ET-1-induced EGFR PTK transactivation in VSMCs. A, B: ET-1-induced EGFR PTK phosphorylation in the presence of 10 μM LOE-908 or 10 μM SK&F-96365 is represented as a percentage of values in its absence. Contributions of store-operated Ca2+channel (SOCCs) and Ca2+-permeable nonselective cation channel (NSCC-1) are represented as X and Z, respectively. Contributions of NSCC-2 are represented asW − Z or Y −X. Yoshifumi Kawanabe et al. Am J Physiol Heart Circ Physiol 2002;283:H2671-H2675 ©2002 by American Physiological Society