Role of DNA Methylation in the Development of Diffuse-Type Gastric Cancer Digestion 2011;83:241–249 - DOI:10.1159/000320453 Fig. 1.a DNA methyltransferases.

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Role of DNA Methylation in the Development of Diffuse-Type Gastric Cancer Digestion 2011;83:241–249 - DOI:10.1159/000320453 Fig. 1.a DNA methyltransferases (DNMTs) catalyze the methylation of cytosine using S-adenosylmethionine (SAM) as the methyl donor. b DNA methylation is maintained after DNA replication by a maintenance DNA methyltransferase, DNMT1. © 2011 S. Karger AG, Basel

Role of DNA Methylation in the Development of Diffuse-Type Gastric Cancer Digestion 2011;83:241–249 - DOI:10.1159/000320453 Fig. 2. Methylation of a CpG island within a gene promoter and transcriptional silencing. a In normal cells, most CpG islands are unmethylated, and gene transcription is active. b In cancer cells, the CpG islands of a number of genes are hypermethylated, which results in transcriptional silencing of the genes. © 2011 S. Karger AG, Basel

Role of DNA Methylation in the Development of Diffuse-Type Gastric Cancer Digestion 2011;83:241–249 - DOI:10.1159/000320453 Fig. 3. Association between fold width, histological type and location of gastric cancers. The results are derived from Nishibayashi et al. [5]. © 2011 S. Karger AG, Basel

Role of DNA Methylation in the Development of Diffuse-Type Gastric Cancer Digestion 2011;83:241–249 - DOI:10.1159/000320453 Fig. 4. Hypothesis for the progression of gastric cancer in H. pylori-induced enlarged-fold gastritis. © 2011 S. Karger AG, Basel