The Postgraduate School of Molecular Medicine 2017 March 15,2017 GENE EXPRESSION AND EPIGENETICS 9.00-9.40 Bozena Kaminska (Nencki Institute, Warsaw) How to decipher epigenetic code? 9.40-10.20 Marta Wisniewska (CENT, University of Warsaw) Advances in genetic tools and alternative animal models in biomedical research 10.20-11.00 Urszula Wojda (Nencki Institute, Warsaw) Alzheimer's disease: development of novel models, biomarkers and therapies 11.00-11.30 Coffee break 11.30-12.10 Jozef Dulak (Jagiellonian University, Krakow) - Role of microRNAs in muscle regeneration and Duchenne muscular dystrophy 12.10 -12.50 Adriana Magalska (Nencki Institute, Warsaw) Chromatin and nuclear architecture remodeling – a new mechanism of epigenetic regulation in the brain 12.50-13.30 break Workshop on biostatistics 13.30-16.00 Wojciech Fendler (Medical University of Lodz) Interactive workshop on biostatistics (personal computers required) Advances in MOLECULAR BIOLOGY AND BIOMEDICINE March 13-15, 2017 Venue: International Institute of Molecular and Cell Biology in Warsaw 4 Ks. Trojdena Str., Warsaw The Postgraduate School of Molecular Medicine

DECIPHERING GENOMES AND Translational medicine March 14, 2017 RNA AND DNA world 9.00-9.40 Marcin Nowotny (International Institute of Molecular and Cell Biology, Warsaw) Cryo-EM - revolution in structural biology 9.40-10.20 Artur Jarmolowski (Adam Mickiewicz University, Poznan) Coupling of RNA Polymerase II transcription elongation with pre-mRNA splicing 10.20-11.00 Jacek Jemielity (CENT, University of Warsaw) mRNA based gene therapy – dream or reality? 11.00-11.30 Coffee break 11.30-12.10 Sebastian Glatt (Malopolska Centre of Biotechnology, Jagiellonian University) Tuning protein production using tRNA modifications 12.10 -12.50 Zofia Szweykowska-Kulinska (Adam Mickiewicz University, Poznan) Posttranscriptional regulation of microRNA expression in Arabidopsis plants 12.50- 13.30 break 13.30-14.10 Andrzej Dziembowski (Institute of Biochemistry and Biophysics/Warsaw University) Exosome and RNA degradation 14.10-14.50 Niels M Frandsen (Exiqon) Silencing of ncRNA with Antisense LNA™ oligonucleotides in cell cultures and in animal models 14.50-15.30 Marianne Rots (University of Groningen, Netherlands) Genome and epigenome editing 15.30-16.10 Jonathan Heddle (Malopolska Centre of Biotechnology, Jagiellonian University) Building artificial nanostructures from biological molecules 16.10-16.40 Zbigniew Gaciong (Medical University of Warsaw) Is personalized medicine a real breakthrough? March 13, 2017 DECIPHERING GENOMES AND Translational medicine 9.30-10.10 Bozena Kaminska (Nencki Institute) Breaking the human genome sequence – hopes and challenges 10.10-10.50 Tomasz Stoklosa (Medical University of Warsaw) Lessons from the studies on the pathogenesis of chronic myeloid leukemia 10.50-11.20 Coffee break 11.20-12.00 Emmanuel Mikros (University of Athens, Greece) From target to drug: medicinal chemistry approaches 12.00-12.40 Cecilia Winata (International Institute of Molecular and Cell Biology, Warsaw) From mother to embryo: gene regulation during early embryogenesis 12.40 -13.20 break 13.20-14.00 Marcin Majka (Jagiellonian University Medical College, Krakow) New look at rhabdomyosarcoma therapy 14.00-14.40 Bartek Wilczynski (University of Warsaw) Integrating diverse datasets for more accurate answers in functional genomics 14.40-15.20 Agnieszka Chacinska (International Institute of Molecular and Cell Biology, Warsaw) Cellular resource and stress management: the case of mitochondria? 15.20-16.00 Jacek Kuznicki (International Institute of Molecular and Cell Biology, Warsaw) Animal models to understand brain diseases