Pedigree Medical Detectives © 2013 Project Lead The Way, Inc.

DO NOW Friday December 2nd Identify the structures in the pictures. D A I C K B F J G H E

DO NOW Monday, December 5th 1. What part of the brain is responsible for Vision? Hearing? Smell? Touch? Planning and problem solving? 2. What part of the brain is the relay station for all senses except smell? 3.What part of the brain is responsible for vital life processes? 4.Why do humans have better higher order thinking and problem-solving skills than most other animals? Occipital lobe Temporal lobe Olfactory bulbs Parietal lobe Frontal lobe Thalamus Brain Stem More developed/bigger frontal lobe

PLAN DO Identify major regions of the human brain. Evaluate patient family history as part of a medical exam and create a pedigree. DO Discuss Jack Brandon’s diagnosis, test recommendations and analysis, and follow-up plans Discuss and draw a pedigree for Jack Brandon’s family Answer the remaining Conclusion questions Practice Brain Anatomy Quiz

Pedigree Analysis Method used to study the inheritance of genes in humans. Can be used to indicate a possible diagnosis of a genetic disorder.

Pedigree Symbols Symbols are used to represent family members.

Pedigree for Jack Brandon Jack’s mom Jack’s dad Jack Jack’s sister Jack’s wife Jack’s daughter

Optional Extension The ability to roll your tongue is a genetic trait. As homework draw a pedigree for your family and for the trait of tongue rolling. If the individual can roll his or her tongue, color in the symbol.

Image Sources By Gideon Tsang from Austin, USA (rolled tongue). [CC-BY-SA-2.0 (http://creativecommons.org/licenses/by-sa/2.0)], via Wikimedia Commons McClean, P. (n.d.). Mendelian genetics. Retrieved from http://www.ndsu.edu/pubweb/~mcclean/plsc431/mendel/mendel9.htm

PLAN DO Identify major regions of the human brain. Evaluate patient family history as part of a medical exam and create a pedigree. DO Brain Quiz Complete a medical history form for sick patient Jack Brandon and do research to make a diagnosis.

Mystery Disease Diagnosis You will work at your table as a team. Complete medical history form for patient Research to make a diagnosis Test Recommendations to confirm diagnosis Explain results of tests (Laboratory Analysis) that would be positive for the disease Follow-up plans (treatment, counseling, etc.) STAY ON TASK DISCUSSION OF PATIENT ONLY Any work not completed during class is homework for tonight.

DO NOW Wednesday September 14th Answer Conclusion Questions 1-3 on page 29 of your biomedical science journal.

DO NOW Tuesday December 6th What structure connects the left and right hemispheres of the cerebrum? Which part of the brain controls muscular movement? Vital life processes? Which part of the brain controls vision? Hearing? Planning and problem solving? Touch? What are some differences between the sheep brain and human brain? Give reasons for these differences.

PLAN DO Identify major regions of the human brain. Analyze how changes in the huntingtin gene affect the resulting protein and nerve cell function. DO Brain Quiz Mystery Disease Part 2- Genetic Testing Answer Conclusion Questions 1-9