Fertility-preservation counselling and treatment for medical reasons: data from a multinational network of over 5000 women  Michael von Wolff, Ralf Dittrich, Jana Liebenthron, Frank Nawroth, Andreas N. Schüring, Thomas Bruckner, Ariane Germeyer  Reproductive BioMedicine Online  Volume 31, Issue 5, Pages 605-612 (November 2015) DOI: 10.1016/j.rbmo.2015.07.013 Copyright © 2015 Reproductive Healthcare Ltd. Terms and Conditions

Figure 1 Total number of counselling sessions and fertility preservation therapies at universities and non-university centres from 2007 until 2013 (overall increase of each category: P < 0.0001). Reproductive BioMedicine Online 2015 31, 605-612DOI: (10.1016/j.rbmo.2015.07.013) Copyright © 2015 Reproductive Healthcare Ltd. Terms and Conditions

Figure 2 Characteristics of women counselled. Proportion of women with and without children (a), distribution of age (b), of diseases (c) and of diseases in relation to age (d) (overall distribution of diseases and of diseases in relation to age: P < 0.0001). Reproductive BioMedicine Online 2015 31, 605-612DOI: (10.1016/j.rbmo.2015.07.013) Copyright © 2015 Reproductive Healthcare Ltd. Terms and Conditions

Figure 3 Percentage of women who selected a particular fertility preservation therapy from 2007 until 2013 (a), in relation to their child status (b), their underlying disease (c) and their age (d). Note: some women chose more than one therapy. GnRHa, GnRH agonists. Reproductive BioMedicine Online 2015 31, 605-612DOI: (10.1016/j.rbmo.2015.07.013) Copyright © 2015 Reproductive Healthcare Ltd. Terms and Conditions

Figure 4 Details of the different fertility preservation therapies such as GnRH agonists (a), ovarian tissue freezing (b) and ovarian stimulation plus oocyte or zygote cryopreservation (c). (a) The percentage of women choosing GnRH agonist as a sole treatment or in combination with other treatments; (b) the percentage of cases in which fewer than one (less than one total ovary) or more than one ovary was removed and cryopreserved; (c) the number of collected oocytes per aspiration on average and in relation to age from 2007 until 2013 (given numbers are rounded for better visualisation). Overall distribution of different treatment combinations with GnRH therapy (a): P = 0.027; overall distribution of cases with fewer than one ovary or one or more ovaries removed (b): P < 0.0001; overall distribution of oocytes in the age groups: P < 0.0001). Reproductive BioMedicine Online 2015 31, 605-612DOI: (10.1016/j.rbmo.2015.07.013) Copyright © 2015 Reproductive Healthcare Ltd. Terms and Conditions