Fig. 1. Time line for investigations

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Fig. 1. Time line for investigations Fig. 1. Time line for investigations. IVGTT, Intravenous glucose tolerance test. From: Randomized, Controlled Trial of Metformin for Obesity and Insulin Resistance in Children and Adolescents: Improvement in Body Composition and Fasting Insulin J Clin Endocrinol Metab. 2006;91(6):2074-2080. doi:10.1210/jc.2006-0241 J Clin Endocrinol Metab | Copyright © 2006 by The Endocrine Society

Fig. 2. CONSORT (Consolidated Standard for Reporting Clinical Trials) flow diagram. From: Randomized, Controlled Trial of Metformin for Obesity and Insulin Resistance in Children and Adolescents: Improvement in Body Composition and Fasting Insulin J Clin Endocrinol Metab. 2006;91(6):2074-2080. doi:10.1210/jc.2006-0241 J Clin Endocrinol Metab | Copyright © 2006 by The Endocrine Society

Fig. 3. Metformin and placebo effect on BMI z-score (top), fasting insulin (middle), and insulin sensitivity (bottom). From: Randomized, Controlled Trial of Metformin for Obesity and Insulin Resistance in Children and Adolescents: Improvement in Body Composition and Fasting Insulin J Clin Endocrinol Metab. 2006;91(6):2074-2080. doi:10.1210/jc.2006-0241 J Clin Endocrinol Metab | Copyright © 2006 by The Endocrine Society