Copyright © 2015 by the American Osteopathic Association. From: Empowering Patients During Insulin Initiation: A Real-World Approach J Am Osteopath Assoc. 2010;110(2):69-78. doi:10.7556/jaoa.2010.110.2.69 Figure Legend: Timeline showing development of diabetes mellitus, illustrating insulin resistance and insulin deficiency. The top graph depicts effects of insulin resistance on endogenous insulin secretion. The bottom graph depicts effects of endogenous insulin deficiency on postprandial blood sugar and fasting blood sugar. From Clinical Diabetes by Ramlo-Halsted BA, Edelman SV.29 Copyright 2000 by American Diabetes Association. Reproduced with permission of American Diabetes Association via Copyright Clearance Center. Date of download: 10/17/2017 Copyright © 2015 by the American Osteopathic Association. All rights reserved.