An Introduction to Muscle Tissue

Slides:



Advertisements
Similar presentations
The Muscular System: Structure and Physiology
Advertisements

Skeletal Muscle Activity: Contraction
A Slides 1 to 110 Copyright © 2007 Pearson Education, Inc., publishing as Benjamin Cummings.
Muscular System Chapter 8.
Muscle Function.
Muscle Tissue and Organization
10 Muscle Tissue.
Muscular system SKELETAL MUSCLE Skeletal muscle is made up of hundreds of muscle fibers –Fibers consists of threadlike myofibrils –Myofibrils composed.
Chapter 9 Muscular System
Anatomy and Physiology I
MUSCLE TISSUE.
Skeletal Muscle Unit Chapter 6.
The Muscular System.
Skeletal Muscle Unit Chapter Functions of skeletal muscles  Produce skeletal movement  Maintain posture and body position  Support soft tissues.
Skeletal Muscles. Anatomy and innervation of skeletal muscle tissue Connective tissue components: –Fascia (“bandage”) –sheet or band of fibrous C.T. under.
Muscle Structure and Function
The Muscular System What do skeletal muscles do? How do muscles work?
Physiological Factors Affecting Testing By Prof. Dr. Samy A. Nasef.
Muscle Physiology Chapter 7.
Lecture # 17: Muscular Tissue
Exercise 14 Microscopic Anatomy, Organization, and
1 Structure of Skeletal Muscle We will begin our look at the structure of muscle starting with the largest structures and working our way down to the smallest.
Muscle Tissue A primary tissue type, divided into: A primary tissue type, divided into: –skeletal muscle –cardiac muscle –smooth muscle.
Essentials of Anatomy and Physiology Fifth edition Seeley, Stephens and Tate Slide 2.1 Copyright © 2003 Pearson Education, Inc. publishing as Benjamin.
Exercise 14 Microscopic Anatomy, Organization, and
Muscular System. Muscle Video Characteristics of Muscles Skeletal and smooth muscle cells are elongated (muscle cell = muscle fiber) Contraction of muscles.
Chapter 11 Physiology of the Muscular System. Introduction Muscular system is responsible for moving the framework of the body In addition to movement,
The Muscular System Slide 6.1 Copyright © 2003 Pearson Education, Inc. publishing as Benjamin Cummings  Muscles are responsible for all types of body.
II. Skeletal Muscle Overview A. Skeletal Muscle Distinguishing Characteristics Striated Voluntary Multi-nucleated B. Functions Movement Maintain Posture.
Three types of muscle Skeletal – attached to bone
Muscles and Muscle Tissue
Chapter 9 Muscular System.
MUSCULAR SYSTEM Structure and Function. Skeletal Muscle Properties 1. Excitability = ability to receive and respond to a stimulus  Also called irritability.
Copyright © 2004 Pearson Education, Inc., publishing as Benjamin Cummings WHOLE MUSCLE CONTRACTION:PART 1 Motor units All the muscle fibers innervated.
Muscular System Chapter 9. Three types of Muscle Tissue  Skeletal  Smooth  Cardiac.
The Muscular System What do skeletal muscles do? How do muscles work?                      
Skeletal Muscle Unit Chapter 6. Functions of skeletal muscles  Produce skeletal movement  Maintain posture and body position  Support soft tissues.
Biol 2401 Biol 2401 Fundamentals of Anatomy and Physiology Mrs. Willie Grant (210)
The Muscular System.
The Muscular System What do skeletal muscles do? How do muscles work?
9 Muscles and Muscle Tissue: Part B-Muscle Contraction and Signal Transmission.
“Introduction to Skeletal Muscle - Histology”
Chapter 6 The Muscular System
The Muscular System What do skeletal muscles do? How do muscles work?
Learning Outcomes 10-1 Identify the common properties of muscle tissues and the primary functions of skeletal muscle Describe the organization of.
Introductory Skeletal Muscle – Histology Flash Cards
Introduction The Muscular System.
Introduction The Muscular System.
Types of Muscle Tissues
Chapter 6 The Muscular System
Physiology of Muscle Contraction
Chapter 6 The Muscular System
Essentials of Anatomy and Physiology
The Muscular System.
Biol 2401 Biol 2401 Fundamentals of Anatomy and Physiology Mrs. Willie Grant (210)
The Muscular System.
Chapter 6 The Muscular System
10 Muscle Tissue.
NOTES: The Muscular System (Ch 8, part 2)
Muscle Contraction and the Sliding Filament Theory
Muscle Fiber Anatomy.
Muscle relationships and types of contractions
Biology 211 Anatomy & Physiology I
10 Muscle Tissue.
MUSLCES PART 2 HOW DO THEY WORK?.
10 Muscle Tissue.
Physiology of Muscle Contraction
Skeletal Muscle Fibers
7 The Muscular System.
Presentation transcript:

An Introduction to Muscle Tissue A primary tissue type, divided into: Skeletal muscle tissue Cardiac muscle tissue Smooth muscle tissue

10-1 Functions of Skeletal Muscle Tissue Skeletal Muscles Are attached to the skeletal system Allow us to move The muscular system Includes only skeletal muscles

10-1 Functions of Skeletal Muscle Tissue Six Functions of Skeletal Muscle Tissue Produce skeletal movement Maintain posture and body position Support soft tissues Guard entrances and exits Maintain body temperature Store nutrient reserves

10-2 Organization of Muscle Skeletal Muscle Muscle tissue (muscle cells or fibers) Connective tissues Nerves Blood vessels

10-2 Organization of Muscle Organization of Connective Tissues Muscles have three layers of connective tissues Epimysium Perimysium Endomysium

10-2 Organization of Muscle Epimysium Exterior collagen layer Connected to deep fascia Separates muscle from surrounding tissues 6

Figure 10-1 The Organization of Skeletal Muscles Skeletal Muscle (organ) Epimysium Perimysium Endomysium Nerve Muscle fascicle Muscle fibers Blood vessels Epimysium Blood vessels and nerves Tendon Endomysium Perimysium 7

10-2 Organization of Muscle Perimysium Surrounds muscle fiber bundles (fascicles) Contains blood vessel and nerve supply to fascicles

Figure 10-1 The Organization of Skeletal Muscles Skeletal Muscle (organ) Epimysium Perimysium Endomysium Nerve Muscle fascicle Muscle fibers Blood vessels Epimysium Blood vessels and nerves Tendon Endomysium Perimysium 9

10-2 Organization of Muscle Endomysium Surrounds individual muscle cells (muscle fibers) Contains capillaries and nerve fibers contacting muscle cells Contains myosatellite cells (stem cells) that repair damage

Figure 10-1 The Organization of Skeletal Muscles Skeletal Muscle (organ) Epimysium Perimysium Endomysium Nerve Muscle fascicle Muscle fibers Blood vessels Epimysium Blood vessels and nerves Tendon Endomysium Perimysium 11

Figure 10-1 The Organization of Skeletal Muscles Muscle Fascicle (bundle of fibers) Perimysium Muscle fiber Epimysium Blood vessels and nerves Endomysium Tendon Endomysium Perimysium 12

Figure 10-1 The Organization of Skeletal Muscles Muscle Fiber (cell) Capillary Myofibril Endomysium Sarcoplasm Epimysium Blood vessels and nerves Mitochondrion Myosatellite cell Sarcolemma Nucleus Tendon Axon of neuron Endomysium Perimysium 13

10-2 Organization of Muscle Organization of Connective Tissues Muscle Attachments Endomysium, perimysium, and epimysium come together: At ends of muscles To form connective tissue attachment to bone matrix I.e., tendon (bundle) or aponeurosis (sheet)

10-2 Organization of Muscle Blood Vessels and Nerves Muscles have extensive vascular systems that: Supply large amounts of oxygen Supply nutrients Carry away wastes Skeletal muscles are voluntary muscles, controlled by nerves of the central nervous system (brain and spinal cord)

10-3 Characteristics of Skeletal Muscle Fibers Skeletal Muscle Cells Are very long Develop through fusion of mesodermal cells (myoblasts) Become very large Contain hundreds of nuclei

Figure 10-2 The Formation of a Multinucleate Skeletal Muscle Fiber Muscle fibers develop through the fusion of mesodermal cells called myoblasts. Myoblasts A muscle fiber forms by the fusion of myoblasts. Muscle fiber LM  612 Nuclei Sarcolemma Myofibrils Myosatellite cell Nuclei Mitochondria Immature muscle fiber A diagrammatic view and a micrograph of one muscle fiber. Myosatellite cell Up to 30 cm in length Mature muscle fiber 17

Figure 10-2a The Formation of a Multinucleate Skeletal Muscle Fiber Muscle fibers develop through the fusion of mesodermal cells called myoblasts. Myoblasts A muscle fiber forms by the fusion of myoblasts. Myosatellite cell Nuclei Immature muscle fiber Myosatellite cell Up to 30 cm in length Mature muscle fiber 18

Figure 10-2b The Formation of a Multinucleate Skeletal Muscle Fiber Nuclei Sarcolemma Myofibrils Mitochondria A diagrammatic view and a micrograph of one muscle fiber. 19

10-3 Characteristics of Skeletal Muscle Fibers The Sarcolemma and Transverse Tubules The sarcolemma The cell membrane of a muscle fiber (cell) Under the endomysium Surrounds the sarcoplasm (cytoplasm of muscle fiber) A change in transmembrane potential begins contractions

Figure 10-3 The Structure of a Skeletal Muscle Fiber Myofibril Sarcolemma Nuclei Sarcoplasm MUSCLE FIBER Mitochondria Terminal cisterna Sarcolemma Sarcolemma Sarcoplasm Myofibril Myofibrils Thin filament Thick filament Triad Sarcoplasmic reticulum T tubules 21

10-3 Characteristics of Skeletal Muscle Fibers The Sarcolemma and Transverse Tubules Transverse tubules (T tubules) Transmit action potential through cell Allow entire muscle fiber to contract simultaneously Have same properties as sarcolemma

Figure 10-3 The Structure of a Skeletal Muscle Fiber Myofibril Sarcolemma Nuclei Sarcoplasm MUSCLE FIBER Mitochondria Terminal cisterna Sarcolemma Sarcolemma Sarcoplasm Myofibril Myofibrils Thin filament Thick filament Triad Sarcoplasmic reticulum T tubules 23

10-3 Characteristics of Skeletal Muscle Fibers Myofibrils Lengthwise subdivisions within muscle fiber Made up of bundles of protein filaments (myofilaments) Myofilaments are responsible for muscle contraction Types of myofilaments: Thin filaments Made of the protein actin Thick filaments Made of the protein myosin

Figure 10-3 The Structure of a Skeletal Muscle Fiber Mitochondria Terminal cisterna Sarcolemma Sarcolemma Sarcoplasm Myofibril Myofibrils Thin filament Thick filament Triad Sarcoplasmic reticulum T tubules 25

10-3 Characteristics of Skeletal Muscle Fibers The Sarcoplasmic Reticulum (SR) A membranous structure surrounding each myofibril Helps transmit action potential to myofibril Similar in structure to smooth endoplasmic reticulum Forms chambers (terminal cisternae) attached to T tubules

Figure 10-3 The Structure of a Skeletal Muscle Fiber Terminal cisterna Sarcolemma Sarcoplasm Myofibrils Triad Sarcoplasmic reticulum T tubules 27

10-3 Characteristics of Skeletal Muscle Fibers The Sarcoplasmic Reticulum (SR) Triad Is formed by one T tubule and two terminal cisternae Cisternae Concentrate Ca2+ (via ion pumps) Release Ca2+ into sarcomeres to begin muscle contraction

Figure 10-3 The Structure of a Skeletal Muscle Fiber Terminal cisterna Sarcolemma Sarcoplasm Myofibrils Triad Sarcoplasmic reticulum T tubules 29

Figure 10-1 The Organization of Skeletal Muscles Skeletal Muscle (organ) Epimysium Perimysium Endomysium Nerve Muscle fascicle Muscle fibers Blood vessels Epimysium Blood vessels and nerves Tendon Endomysium Perimysium 30

Figure 10-1 The Organization of Skeletal Muscles Muscle Fascicle (bundle of fibers) Perimysium Muscle fiber Epimysium Blood vessels and nerves Endomysium Tendon Endomysium Perimysium 31

Figure 10-1 The Organization of Skeletal Muscles Muscle Fiber (cell) Capillary Myofibril Endomysium Sarcoplasm Epimysium Blood vessels and nerves Mitochondrion Myosatellite cell Sarcolemma Nucleus Tendon Axon of neuron Endomysium Perimysium 32

Figure 10-3 The Structure of a Skeletal Muscle Fiber Myofibril Sarcolemma Nuclei Sarcoplasm MUSCLE FIBER Mitochondria Terminal cisterna Sarcolemma Sarcolemma Sarcoplasm Myofibril Myofibrils Thin filament Thick filament Triad Sarcoplasmic reticulum T tubules 33

Figure 10-3 The Structure of a Skeletal Muscle Fiber Myofibril Sarcolemma Nuclei Sarcoplasm MUSCLE FIBER 34

Figure 10-3 The Structure of a Skeletal Muscle Fiber Mitochondria Terminal cisterna Sarcolemma Sarcolemma Sarcoplasm Myofibril Myofibrils Thin filament Thick filament Triad Sarcoplasmic reticulum T tubules 35

Figure 10-3 The Structure of a Skeletal Muscle Fiber Mitochondria Sarcolemma Myofibril Thin filament Thick filament 36

Figure 10-3 The Structure of a Skeletal Muscle Fiber Terminal cisterna Sarcolemma Sarcoplasm Myofibrils Triad Sarcoplasmic reticulum T tubules 37

Perimysium Muscle Epimysium Muscle fiber Endomysium Muscle fascicle Tendon

Figure 10-3 The Structure of a Skeletal Muscle Fiber Myofibrils Sarcoplasmic reticulum Myofibril T-tubules Sarcomere Triad Sarcolemma 39

10-3 Structural Components of a Sarcomere Sarcomeres The contractile units of muscle Structural units of myofibrils Form visible patterns within myofibrils A striped or striated pattern within myofibrils Alternating dark, thick filaments (A bands) and light, thin filaments (I bands)

Figure 10-4a Sarcomere Structure, Part I I band A band H band Z line Titin A longitudinal section of a sarcomere, showing bands Zone of overlap M line Thin filament Thick filament Sarcomere 41

10-3 Structural Components of a Sarcomere Sarcomeres The A Band M line At midline of sarcomere The H Band Has thick filaments but no thin filaments Zone of overlap The densest, darkest area on a light micrograph Where thick and thin filaments overlap

Figure 10-4a Sarcomere Structure, Part I I band A band H band Z line Titin A longitudinal section of a sarcomere, showing bands Zone of overlap M line Thin filament Thick filament Sarcomere 43

10-3 Structural Components of a Sarcomere Sarcomeres The I Band Z lines At two ends of sarcomere Titin Stabilize the filaments

Figure 10-4a Sarcomere Structure, Part I I band A band H band Z line Titin A longitudinal section of a sarcomere, showing bands Zone of overlap M line Thin filament Thick filament Sarcomere 45

Figure 10-4b Sarcomere Structure, Part I I band A band H band Z line A corresponding view of a sarcomere in a myofibril from a muscle fiber in the gastrocnemius muscle of the calf Myofibril TEM  64,000 Z line Zone of overlap M line Sarcomere 46

Figure 10-5 Sarcomere Structure, Part II Myofibril A superficial view of a sarcomere Thin filament Thick filament Actinin filaments Titin filament Attachment of titin Z line I band M line H band Zone of overlap Cross-sectional views of different portions of a sarcomere 47

Figure 10-6 Levels of Functional Organization in a Skeletal Muscle Myofibril Surrounded by: Epimysium Surrounded by: Sarcoplasmic reticulum Epimysium Contains: Muscle fascicles Consists of: Sarcomeres (Z line to Z line) Sarcomere I band A band Muscle Fascicle Contains: Thick filaments Surrounded by: Perimysium Thin filaments Perimysium Contains: Muscle fibers Z line M line Titin Z line H band Muscle Fiber Surrounded by: Endomysium Endomysium Contains: Myofibrils 48

Figure 10-6 Levels of Functional Organization in a Skeletal Muscle Surrounded by: Epimysium Epimysium Contains: Muscle fascicles 49

Figure 10-6 Levels of Functional Organization in a Skeletal Muscle Muscle Fascicle Surrounded by: Perimysium Perimysium Contains: Muscle fibers 50

Figure 10-6 Levels of Functional Organization in a Skeletal Muscle Muscle Fiber Surrounded by: Endomysium Endomysium Contains: Myofibrils 51

Figure 10-6 Levels of Functional Organization in a Skeletal Muscle Myofibril Surrounded by: Sarcoplasmic reticulum Consists of: Sarcomeres (Z line to Z line) 52

Figure 10-6 Levels of Functional Organization in a Skeletal Muscle Sarcomere I band A band Contains: Thick filaments Thin filaments Z line M line Titin Z line H band 53

Figure 10-7b Thick and Thin Filaments Troponin Active site Nebulin Tropomyosin G-actin molecules F-actin strand The organization of G-actin subunits in an F-actin strand, and the position of the troponin–tropomyosin complex 54

Figure 10-7cd Thick and Thin Filaments Titin The structure of thick filaments, showing the orientation of the myosin molecules M line Myosin head Myosin tail Hinge The structure of a myosin molecule 55

10-3 Structural Components of a Sarcomere Thin Filament Nebulin The center of the thin filament G-actin The active sites on actin strands bind to myosin

10-3 Structural Components of a Sarcomere Thin Filaments Tropomyosin Prevents actin–myosin interaction Troponin Controlled by Ca2+

Figure 10-7ab Thick and Thin Filaments Sarcomere H band Actinin Z line Titin Myofibril The gross structure of a thin filament, showing the attachment at the Z line Troponin Active site Nebulin Tropomyosin G-actin molecules Z line M line F-actin strand The organization of G-actin subunits in an F-actin strand, and the position of the troponin–tropomyosin complex 58

Figure 10-7a Thick and Thin Filaments Actinin Z line Titin The gross structure of a thin filament, showing the attachment at the Z line 59

Figure 10-7b Thick and Thin Filaments Troponin Active site Nebulin Tropomyosin G-actin molecules F-actin strand The organization of G-actin subunits in an F-actin strand, and the position of the troponin–tropomyosin complex 60

Figure 10-7b Thick and Thin Filaments Troponin Active site Nebulin Tropomyosin G-actin molecules F-actin strand The organization of G-actin subunits in an F-actin strand, and the position of the troponin–tropomyosin complex 61

10-3 Structural Components of a Sarcomere Initiating Contraction Ca2+ binds to receptor on troponin molecule Troponin pulls tropomyosin away from f-actin Exposes active site of F-actin

10-3 Structural Components of a Sarcomere Thick Filaments Contain about 300 twisted myosin subunits Contain titin strands that recoil after stretching The mysosin molecule Tail Binds to other myosin molecules Head Made of two protein subunits Reaches the nearest thin filament

Figure 10-7cd Thick and Thin Filaments Titin The structure of thick filaments, showing the orientation of the myosin molecules M line Myosin head Myosin tail Hinge The structure of a myosin molecule 64

10-3 Structural Components of a Sarcomere Myosin Action During contraction, myosin heads: Interact with actin filaments, forming cross-bridges Pivot, producing motion

10-3 Structural Components of a Sarcomere Sliding Filaments and Muscle Contraction Sliding filament theory Thin filaments of sarcomere slide toward M line, alongside thick filaments The width of A zone stays the same Z lines move closer together

Figure 10-8a Changes in the Appearance of a Sarcomere during the Contraction of a Skeletal Muscle Fiber I band A band Z line H band Z line A relaxed sarcomere showing location of the A band, Z lines, and I band. 67

Figure 10-8b Changes in the Appearance of a Sarcomere during the Contraction of a Skeletal Muscle Fiber I band A band Z line H band Z line During a contraction, the A band stays the same width, but the Z lines move closer together and the I band gets smaller. When the ends of a myofibril are free to move, the sarcomeres shorten simultaneously and the ends of the myofibril are pulled toward its center. 68

10-3 Structural Components of a Sarcomere Skeletal Muscle Contraction The process of contraction Neural stimulation of sarcolemma Muscle fiber contraction Tension production

Figure 10-9 An Overview of Skeletal Muscle Contraction Neural control Excitation–contraction coupling Excitation Calcium release triggers ATP Thick-thin filament interaction Muscle fiber contraction leads to Tension production 70

Figure 10-9 An Overview of Skeletal Muscle Contraction Neural control 71

Figure 10-9 An Overview of Skeletal Muscle Contraction Excitation Calcium release ATP triggers Thick-thin filament interaction 72

Figure 10-9 An Overview of Skeletal Muscle Contraction Muscle fiber contraction leads to Tension production 73

10-4 Components of the Neuromuscular Junction The Control of Skeletal Muscle Activity The neuromuscular junction (NMJ) Between nervous system and skeletal muscle fiber Stimulates release of calcium ions into sarcoplasm

Figure 10-11 Skeletal Muscle Innervation Motor neuron Path of electrical impulse (action potential) Axon Neuromuscular junction Synaptic terminal SEE BELOW Sarcoplasmic reticulum Motor end plate Myofibril Motor end plate 75

Figure 10-11 Skeletal Muscle Innervation The cytoplasm of the synaptic terminal contains vesicles filled with molecules of acetylcholine, or ACh. Acetylcholine is a neurotransmitter, a chemical released by a neuron to change the permeability or other properties of another cell’s plasma membrane. The synaptic cleft and the motor end plate contain molecules of the enzyme acetylcholinesterase (AChE), which breaks down ACh. Vesicles ACh The synaptic cleft, a narrow space, separates the synaptic terminal of the neuron from the opposing motor end plate. Junctional fold of motor end plate AChE 76

Figure 10-11 Skeletal Muscle Innervation The stimulus for ACh release is the arrival of an electrical impulse, or action potential, at the synaptic terminal. An action potential is a sudden change in the transmembrane potential that travels along the length of the axon. Arriving action potential 77

Figure 10-11 Skeletal Muscle Innervation When the action potential reaches the neuron’s synaptic terminal, permeability changes in the membrane trigger the exocytosis of ACh into the synaptic cleft. Exocytosis occurs as vesicles fuse with the neuron’s plasma membrane. Motor end plate 78

Figure 10-11 Skeletal Muscle Innervation ACh molecules diffuse across the synatpic cleft and bind to ACh receptors on the surface of the motor end plate. ACh binding alters the membrane’s permeability to sodium ions. Because the extracellular fluid contains a high concentration of sodium ions, and sodium ion concentration inside the cell is very low, sodium ions rush into the sarcoplasm. ACh receptor site 79

Figure 10-11 Skeletal Muscle Innervation The sudden inrush of sodium ions results in the generation of an action potential in the sarcolemma. AChE quickly breaks down the ACh on the motor end plate and in the synaptic cleft, thus inactivating the ACh receptor sites. Action potential AChE 80

10-4 Components of the Neuromuscular Junction Excitation–Contraction Coupling Action potential reaches a triad Releasing Ca2+ Triggering contraction Requires myosin heads to be in “cocked” position Loaded by ATP energy

Figure 10-10 The Exposure of Active Sites SARCOPLASMIC RETICULUM Calcium channels open Myosin tail (thick filament) Tropomyosin strand Troponin G-actin (thin filament) Active site Nebulin In a resting sarcomere, the tropomyosin strands cover the active sites on the thin filaments, preventing cross-bridge formation. When calcium ions enter the sarcomere, they bind to troponin, which rotates and swings the tropomyosin away from the active sites. Cross-bridge formation then occurs, and the contraction cycle begins. 82

10-4 Skeletal Muscle Contraction The Contraction Cycle Contraction Cycle Begins Active-Site Exposure Cross-Bridge Formation Myosin Head Pivoting Cross-Bridge Detachment Myosin Reactivation

Figure 10-12 The Contraction Cycle Contraction Cycle Begins The contraction cycle, which involves a series of interrelated steps, begins with the arrival of calcium ions within the zone of overlap. Myosin head Troponin Tropomyosin Actin 84

Figure 10-12 The Contraction Cycle Active-Site Exposure Calcium ions bind to troponin, weakening the bond between actin and the troponin– tropomyosin complex. The troponin molecule then changes position, rolling the tropomyosin molecule away from the active sites on actin and allowing interaction with the energized myosin heads. Sarcoplasm Active site 85

Figure 10-12 The Contraction Cycle Cross-Bridge Formation Once the active sites are exposed, the energized myosin heads bind to them, forming cross-bridges. 86

Figure 10-12 The Contraction Cycle Myosin Head Pivoting After cross-bridge formation, the energy that was stored in the resting state is released as the myosin head pivots toward the M line. This action is called the power stroke; when it occurs, the bound ADP and phosphate group are released. 87

Figure 10-12 The Contraction Cycle Cross-Bridge Detachment When another ATP binds to the myosin head, the link between the myosin head and the active site on the actin molecule is broken. The active site is now exposed and able to form another cross-bridge. 88

Figure 10-12 The Contraction Cycle Myosin Reactivation Myosin reactivation occurs when the free myosin head splits ATP into ADP and P. The energy released is used to recock the myosin head. 89