Immunological synapse

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Presentation transcript:

Immunological synapse

Randriamampita C. et al., Biol. of the Cell, 2004

Davis D.M. Sci. Am., Feb., 2006

PKCq Talin Monks CR. et al, Nature, 395, 1998

Central Supramolecular Activation Cluster (cSMAC) Monks CR. et al, Nature, 395, 1998

Two main questions 1. What is the function of IS? 2. What drives its formation?

Feske S., Nat. Rev. Immunol., Sep. 2007

Calcium mobilization Bunnell SC. et al, J. Cell Biol., 158, 2002

Barda-Saad M. et al., Nature Immunol. 6, 2005

Mossman KD. et al., Science, 310, 2005

Mossman KD. et al., Science, 310, 2005

Saito T., et al., Curr. Opin. Immunol., 18, 2006

Saito T., et al., Curr. Opin. Immunol., 18, 2006

Central Supramolecular deActivation Cluster (cSMAC) Monks CR. et al, Nature, 395, 1998

What drives formation of microclusters and the immunological synapse? Lipid rafts? Protein-protein interactions? Cytoskeleton?

Dykstra M. et al, Annu. Rev. Immunol., 2003

Feske S., Nat. Rev. Immunol., Sep. 2007

Laurdan staining of membranes Gaus K. et al., J. Cell Biol., 171, 2005

Lillimeier BF., PNAS, 103, 2006

Lillimeier BF., PNAS, 103, 2006

Barda-Saad M. et al., Nature Immunol. 6, 2005

? Harder T. et al., Curr. Opin. Immunol.,19, 2007