Immunological synapse
Randriamampita C. et al., Biol. of the Cell, 2004
Davis D.M. Sci. Am., Feb., 2006
PKCq Talin Monks CR. et al, Nature, 395, 1998
Central Supramolecular Activation Cluster (cSMAC) Monks CR. et al, Nature, 395, 1998
Two main questions 1. What is the function of IS? 2. What drives its formation?
Feske S., Nat. Rev. Immunol., Sep. 2007
Calcium mobilization Bunnell SC. et al, J. Cell Biol., 158, 2002
Barda-Saad M. et al., Nature Immunol. 6, 2005
Mossman KD. et al., Science, 310, 2005
Mossman KD. et al., Science, 310, 2005
Saito T., et al., Curr. Opin. Immunol., 18, 2006
Saito T., et al., Curr. Opin. Immunol., 18, 2006
Central Supramolecular deActivation Cluster (cSMAC) Monks CR. et al, Nature, 395, 1998
What drives formation of microclusters and the immunological synapse? Lipid rafts? Protein-protein interactions? Cytoskeleton?
Dykstra M. et al, Annu. Rev. Immunol., 2003
Feske S., Nat. Rev. Immunol., Sep. 2007
Laurdan staining of membranes Gaus K. et al., J. Cell Biol., 171, 2005
Lillimeier BF., PNAS, 103, 2006
Lillimeier BF., PNAS, 103, 2006
Barda-Saad M. et al., Nature Immunol. 6, 2005
? Harder T. et al., Curr. Opin. Immunol.,19, 2007