Novel Methodology to Evaluate Renal Cysts in Polycystic Kidney Disease

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Novel Methodology to Evaluate Renal Cysts in Polycystic Kidney Disease Am J Nephrol 2014;39:210-217 - DOI:10.1159/000358604 Fig. 1. Mid-slice MR images from an ADPKD patient with mild cyst burden illustrating the initial segmented kidney (a), manual cyst counting (b) and individual cysts segmented using the semiautomated method (c). a Cysts were scattered and discretely defined by surrounding renal parenchyma. Most cysts were well separated without touching each other. b The manual counting method was performed using an in-house cyst-labeling computer program. Small, poorly defined foci of faint brightness were not counted as cysts because they were difficult to differentiate from background MR image noise in the parenchyma. c Individual renal cysts were segmented and color-coded using the semiautomated method. © 2014 S. Karger AG, Basel

Novel Methodology to Evaluate Renal Cysts in Polycystic Kidney Disease Am J Nephrol 2014;39:210-217 - DOI:10.1159/000358604 Fig. 2. Mid-slice MR images from an ADPKD patient with severe cyst burden illustrating the initial segmented kidney (a), manual cyst counting (b) and individual cysts segmented using the semiautomated method (c). a The kidney was diffusely occupied by numerous cysts with barely discernible renal parenchyma. Some neighboring cysts shared borders. b Individual cysts were manually flagged and counted using an in-house cyst-labeling computer program. c Individual renal cysts were segmented and color-coded using the semiautomated method. © 2014 S. Karger AG, Basel

Novel Methodology to Evaluate Renal Cysts in Polycystic Kidney Disease Am J Nephrol 2014;39:210-217 - DOI:10.1159/000358604 Fig. 3. Scatter plot of manual versus semiautomated renal cyst counts for the right (a) and left kidney (b). The two methods correlated well (right kidney: ICC 0.96, 95% CI 0.95-0.97; left kidney: ICC 0.96, 95% CI 0.95-0.97). Diagonal lines represent the line of identity. © 2014 S. Karger AG, Basel

Novel Methodology to Evaluate Renal Cysts in Polycystic Kidney Disease Am J Nephrol 2014;39:210-217 - DOI:10.1159/000358604 Fig. 4. Bland-Altman plot for manual versus semiautomated renal cyst counts for the right (a) and left kidney (b). © 2014 S. Karger AG, Basel