San Antonio Breast Cancer Symposium - December 6-10, 2011 Pre-operative haematological markers and prognosis in early breast cancer Cordiner RL1, Mansell J1, Obondo CA1, Angerson WJ1, Lannigan A2, McMillan DC1, Wilson CR1, Doughty JC1. 1. Western Infirmary, Glasgow, UK. 2. Wishaw General Hospital, Wishaw, UK. Background Systemic inflammation may influence survival in breast cancer Both the Platelet Lymphocyte Ratio (PLR) and the Neutrophil Lymphocyte ratio (NLR) have been shown to be associated with survival in a number of solid tumours Aims To establish if there is a relationship between PLR and NLR with clinicopathological characteristics and cancer specific survival in early breast cancer Methods Women diagnosed with early breast cancer between 2003 and 2006 were included Two centres in the west of Scotland region Pre-operative differential white cell count, including lymphocyte and neutrophil count, and platelet count were measured pre-operatively Kaplan-Meier and Cox regression survival analysis was performed Breast cancer specific survival was the primary endpoint Association between markers of inflammation and clinicopathological characteristics were analysed using Chi squared test. Figure 2. Kaplan-Meier survival analysis related to PLR (Log rank p value 0.869) Figure 1. Kaplan Meier survival analysis related to NLR (Log rank p value 0.752) Results 707 women were included Median follow up was 3.7yrs . The median NLR was 2.63. The median PLR was 163.7 Clinicopathological and treatment characteristics along with univariate analysis for survival are shown in table 1. Using Kaplan-Meier survival analysis neither NLR or PLR was shown to predict cancer specific survival (Fig. 1 & 2) A trend towards a significant association between PLR and tumour grade was seen (Table 2) Conclusions In this preliminary study neither NLR or PLR was shown to predict breast cancer specific survival The limited cohort size with relatively short follow up may under represent the effect of these two potential prognostic factors However standard tumour related prognostic variables remained significant predictors of breast cancer survival so any effect that the NLR or PLR may have is likely to be small. Table 1. Clinical and pathological charactersitics and survival Table 2. Association between PLR and tumour grade This presentation is the intellectual property of JC Doughty. Contact at j.c.doughty@clinmed.gla.ac.uk for permission to reprint and/or distribute.