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Copyright © 2005 American Medical Association. All rights reserved. From: Systematic Review and Meta-analysis of Short-Acting Insulin Analogues in Patients With Diabetes Mellitus Arch Intern Med. 2005;165(12):1337-1344. doi:10.1001/archinte.165.12.1337 Figure Legend: Flowchart providing numbers of randomized controlled trials (RCTs) identified, excluded for various reasons, and included in the systematic review and meta-analysis. HbA1c indicates glycosylated hemoglobin A1c. Date of download: 10/18/2017 Copyright © 2005 American Medical Association. All rights reserved.

Copyright © 2005 American Medical Association. All rights reserved. From: Systematic Review and Meta-analysis of Short-Acting Insulin Analogues in Patients With Diabetes Mellitus Arch Intern Med. 2005;165(12):1337-1344. doi:10.1001/archinte.165.12.1337 Figure Legend: Differences in hemoglobin A1c (HbA1c) values. A, Weighted mean differences (error bars indicate 95% confidence interval [CI]) in HbA1c percentage values during therapy with short-acting insulin (SAI) analogues compared with structurally unchanged SAI in patients with type 1 diabetes mellitus. B, Weighted mean differences (error bars indicate 95% CI) in overall hypoglycemic event rate during therapy with SAI analogues compared with structurally unchanged SAI in patients with type 2 diabetes mellitus. Date of download: 10/18/2017 Copyright © 2005 American Medical Association. All rights reserved.

Copyright © 2005 American Medical Association. All rights reserved. From: Systematic Review and Meta-analysis of Short-Acting Insulin Analogues in Patients With Diabetes Mellitus Arch Intern Med. 2005;165(12):1337-1344. doi:10.1001/archinte.165.12.1337 Figure Legend: Differences in overall hypoglycemic event rate. A, Standardized mean differences (error bars indicate 95% confidence interval [CI]) in overall hypoglycemic event rate during therapy with short-acting insulin (SAI) analogues compared with structurally unchanged SAI in patients with type 1 diabetes mellitus. B, Standardized mean differences (error bars indicate 95% CI) in overall hypoglycemic event rate during therapy with SAI analogues compared with structurally unchanged SAI in patients with type 2 diabetes mellitus. Date of download: 10/18/2017 Copyright © 2005 American Medical Association. All rights reserved.