Stereotactic Body Radiation Therapy for Locally Advanced and Borderline Resectable Pancreatic Cancer Is Effective and Well Tolerated Michael D. Chuong,

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Presentation transcript:

Stereotactic Body Radiation Therapy for Locally Advanced and Borderline Resectable Pancreatic Cancer Is Effective and Well Tolerated Michael D. Chuong, MD, Gregory M. Springett, MD, PhD, Jessica M. Freilich, MD, Catherine K. Park, MD, MPH, Jill M. Weber, MPH, Eric A. Mellon, MD, PhD, Pamela J. Hodul, MD, Mokenge P. Malafa, MD, Kenneth L. Meredith, MD, Sarah E. Hoffe, MD, Ravi Shridhar, MD, PhD International Journal of Radiation Oncology • Biology • Physics Volume 86, Issue 3, Pages 516-522 (July 2013) DOI: 10.1016/j.ijrobp.2013.02.022 Copyright © 2013 Terms and Conditions

Fig. 1 (A) Staging computed tomography (CT) scan of patient with borderline resectable pancreatic cancer with near complete occlusion of the SMV at the tumor-vessel interface (arrow). (B) Typical isodose lines encompass the region of vessel involvement that is prescribed a higher dose per fraction than the remainder of the tumor. (C) Restaging scans showing a dramatic response with restoration of blood flow to the SMV (arrow). D = duodenum. International Journal of Radiation Oncology • Biology • Physics 2013 86, 516-522DOI: (10.1016/j.ijrobp.2013.02.022) Copyright © 2013 Terms and Conditions

Fig. 2 (A) Kaplan-Meier analysis of overall survival for patients with borderline resectable and locally advanced pancreatic cancer. (B) Kaplan-Meier analysis of progression-free survival for patients with borderline resectable and locally advanced pancreatic cancer. International Journal of Radiation Oncology • Biology • Physics 2013 86, 516-522DOI: (10.1016/j.ijrobp.2013.02.022) Copyright © 2013 Terms and Conditions

Fig. 3 (A) Kaplan-Meier analysis of overall survival for surgically resected versus nonsurgical patients. (B) Kaplan-Meier analysis of progression-free survival for surgically resected versus nonsurgical patients. International Journal of Radiation Oncology • Biology • Physics 2013 86, 516-522DOI: (10.1016/j.ijrobp.2013.02.022) Copyright © 2013 Terms and Conditions