Cushing's disease Xavier Bertagna, MD, PhD, Laurence Guignat, MD, Lionel Groussin, MD, PhD, Jérôme Bertherat, MD, PhD Best Practice & Research Clinical.

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Presentation transcript:

Cushing's disease Xavier Bertagna, MD, PhD, Laurence Guignat, MD, Lionel Groussin, MD, PhD, Jérôme Bertherat, MD, PhD Best Practice & Research Clinical Endocrinology & Metabolism Volume 23, Issue 5, Pages 607-623 (October 2009) DOI: 10.1016/j.beem.2009.06.001 Copyright © 2009 Elsevier Ltd Terms and Conditions

Fig. 1 (A & B) Typical aspect of a patient with Cushing's syndrome: centripetal fat depositing with truncal obesity contrasting with the muscular atrophy of the thighs and legs (Personal collection). Best Practice & Research Clinical Endocrinology & Metabolism 2009 23, 607-623DOI: (10.1016/j.beem.2009.06.001) Copyright © 2009 Elsevier Ltd Terms and Conditions

Fig. 2 Pituitary corticotroph adenoma revealed by MRI in Cushing's disease. A typical hypointense signal is observed with T1-weighted images after gadolinium injection (Personal collection). Best Practice & Research Clinical Endocrinology & Metabolism 2009 23, 607-623DOI: (10.1016/j.beem.2009.06.001) Copyright © 2009 Elsevier Ltd Terms and Conditions

Fig. 3 Diagnostic flow-chart in a patient with clinical suspicion of Cushing's syndrome. Best Practice & Research Clinical Endocrinology & Metabolism 2009 23, 607-623DOI: (10.1016/j.beem.2009.06.001) Copyright © 2009 Elsevier Ltd Terms and Conditions