Introduction Methodology Objective Results & Discussion Conclusion

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Introduction Methodology Objective Results & Discussion Conclusion International Conference on Antioxidants and Degenerative Diseases (ICADD), Kuala Lumpur, Malaysia 3rd - 4th June 2015 The Elevation of Secretory Phospholipase A2 Group IIA (sPLA2-IIa) Level and Neutrophil Count among Sepsis Syndrome Patients NS Ahmad1, TL Tan 2, K Tajul Arifin1, WZ Wan Ngah1 1Department of Biochemistry, 2Department of Emergency Medicine, Faculty of Medicine, Universiti Kebangsaan Malaysia Medical Centre, Jalan Yaacob Latif, Bandar Tun Razak, 56000 Cheras, Kuala Lumpur. Sepsis is systemic inflammatory response towards infection1. Secretory phospholipase A2 Group IIA (sPLA2-IIa) and neutrophil count are potential biomarkers for sepsis specifically caused by bacteria2. Neutrophil activation at certain level may not be indicative of bacterial infections2,3. Whereas sPLA2-IIa may be more specific for generating bioactive lysophopholids resulting in inflammation caused by bacteria4. Introduction Methodology Inclusion criteria: Age 18 years old and above Suspected sepsis patients resented in Department of Emergency Medicine, UKMMC Exclusion criteria: Subject who did not give consent Clotted blood sample Objective The aim of this study is to compare the level of secretory phospholipase A2 Group IIA (sPLA2-IIa) and neutrophil count among non-sepsis, sepsis, severe sepsis and septic shock patients. Results & Discussion Demographic n % Age (mean ± s.d) 51.85 ± 21.72 Gender Male 52 50.5 Female 51 49.5 Race Malay 57 55.3 Chinese 32 31.1 Indian 10 9.7 Others 4 3.9 50 100 40 80 30 sPLA2-IIa level (ng/ml) 60 Neutrophil count (%) 20 40 10 20 Sepsis category Sepsis category Figure 1 showed demographic data of suspected sepsis patients presented in Department of Emergency Medicine from March to June 2014 Figure 2 showed that sPLA2-IIa level was significantly increased according to the severity of sepsis (P<0.05). Figure 3 showed that neutrophil count was significantly increased according to the severity of sepsis (P<0.05). Conclusion References: Fry DE (2012) Sepsis, Systemic Inflammatory Response, and Multiple Organ Dysfunction: The Mystery Continues. Am Surg 78(1):1-8 Pierrakos, C., & Vincent, J.L (2010) Sepsis biomarkers: a review. Critical Care 14, R15. R. Levy, R. Dana, I. Hazan, I. Levy, G. Weber, R. Smoliakov, I. Pesach, K. Riesenberg, and F. Schlaeffer (2000) Elevated cytosolic phospholipaseA2 expression and activity in human neutrophils during sepsis. Blood Journal 95:660-665. Mearelli F, Fiotti N, Altamura N, Zanetti M, Fernandes G, Burekovic I, Occhipinti A, Orso D, Giansante C, Casarsa C, Biolo G (2014) Heterogeneous models for an early discrimination between sepsis and non-infective SIRS in medical ward patients: a pilot study. Intern Emerg Med 9(7):749-57. The sPLA2-IIa level and neutrophil count are increased significantly according to severity of sepsis and they could be used as sepsis biomarkers. Acknowledgement: This study has been supported by Economic Transformation Program fund (Research code: ETP-2013-050) from Universiti Kebangsaan Malaysia.