Animal Physiology Review A Visual Review Chapters 11-Cell Communication Chapter 43-Immune System Chapter 48-Neurons, Synapses and Signaling Chapter 45-Hormones and Endocrine Chapter 40-Homeostasis

Figure 40.6 Signaling in the endocrine and nervous systems 2

Figure 40.UN01 Summary figure, Concept 40.2 3

Negative Feedback Loop-Blood Sugar

Positive Feedback-Uterine Contractions

Figure 40.16 Figure 40.16 The thermostatic function of the hypothalamus in human thermoregulation. 6

S cells of duodenum secrete the hormone secretin ( ). Figure 45.11 Pathway Example  Stimulus Low pH in duodenum S cells of duodenum secrete the hormone secretin ( ). Endocrine cell Hormone Negative feedback Figure 45.11 A simple endocrine pathway. Blood vessel Target cells Pancreas Response Bicarbonate release

Hypothalamus/ posterior pituitary Figure 45.12 Pathway Example  Stimulus Suckling Sensory neuron Hypothalamus/ posterior pituitary Posterior pituitary secretes the neurohormone oxytocin ( ). Neurosecretory cell Positive feedback Neurohormone Blood vessel Figure 45.12 A simple neuroendocrine pathway. Target cells Smooth muscle in breasts Response Milk release

Peripheral nervous system (PNS) Central nervous system (CNS) Figure 48.3 Sensory input Integration Sensor Motor output Figure 48.3 Summary of information processing. Effector Peripheral nervous system (PNS) Central nervous system (CNS) 9

Presynaptic cell Synaptic cleft Figure 48.15 Presynaptic cell Postsynaptic cell Axon Synaptic vesicle containing neurotransmitter 1 Postsynaptic membrane Synaptic cleft Presynaptic membrane 3 Figure 48.15 A chemical synapse. K Ca2 2 Voltage-gated Ca2 channel Ligand-gated ion channels 4 Na 10

Sodium- potassium pump Figure 48.7 Key Na K Sodium- potassium pump OUTSIDE OF CELL Potassium channel Sodium channel Figure 48.7 The basis of the membrane potential. INSIDE OF CELL 11

Falling phase of the action potential 3 Figure 48.11-5 Key Na K 4 Falling phase of the action potential 3 Rising phase of the action potential 50 Action potential 3 Membrane potential (mV) Threshold 4 2 50 1 1 5 2 Depolarization Resting potential 100 Figure 48.11 The role of voltage-gated ion channels in the generation of an action potential. Time OUTSIDE OF CELL Sodium channel Potassium channel INSIDE OF CELL Inactivation loop 1 Resting state 5 Undershoot 12

Nucleus of Schwann cell Axon Myelin sheath Figure 48.13 Node of Ranvier Layers of myelin Axon Schwann cell Schwann cell Nodes of Ranvier Nucleus of Schwann cell Axon Myelin sheath Figure 48.13 Schwann cells and the myelin sheath. 0.1 m 13

Pathogens (such as bacteria, fungi, and viruses) Figure 43.2 Pathogens (such as bacteria, fungi, and viruses) INNATE IMMUNITY (all animals) Barrier defenses: Skin Mucous membranes Secretions Recognition of traits shared by broad ranges of pathogens, using a small set of receptors • Internal defenses: Phagocytic cells Natural killer cells Antimicrobial proteins Inflammatory response • Rapid response Figure 43.2 Overview of animal immunity. ADAPTIVE IMMUNITY (vertebrates only) Humoral response: Antibodies defend against infection in body fluids. Recognition of traits specific to particular pathogens, using a vast array of receptors • Cell-mediated response: Cytotoxic cells defend against infection in body cells. • Slower response

Mast cell Red blood cells Figure 43.8-3 Pathogen Splinter Macro- phage Movement of fluid Signaling molecules Mast cell Capillary Phagocytosis Figure 43.8 Major events in a local inflammatory response. Red blood cells Neutrophil

(a) B cell antigen receptors and antibodies Figure 43.10 Antigen receptor Antibody B cell Antigen Epitope Pathogen (a) B cell antigen receptors and antibodies Antibody C Figure 43.10 Antigen recognition by B cells and antibodies. Antibody A Antibody B Antigen (b) Antigen receptor specificity

Displayed antigen fragment T cell Figure 43.12 Displayed antigen fragment T cell T cell antigen receptor MHC molecule Antigen fragment Pathogen Host cell (a) Antigen recognition by a T cell Top view Figure 43.12 Antigen recognition by T cells. Antigen fragment MHC molecule Host cell (b) A closer look at antigen presentation

Humoral (antibody-mediated) immune response Figure 43.20 Humoral (antibody-mediated) immune response Cell-mediated immune response Key Antigen (1st exposure)  Stimulates Engulfed by Gives rise to Antigen- presenting cell    B cell Helper T cell Cytotoxic T cell   Memory helper T cells Figure 43.20 An overview of the adaptive immune response.    Antigen (2nd exposure)  Memory cytotoxic T cells Active cytotoxic T cells Plasma cells Memory B cells Secreted antibodies Defend against extracellular pathogens Defend against intracellular pathogens and cancer

Figure 11.5 Local signaling Long-distance signaling Target cell Electrical signal along nerve cell triggers release of neurotransmitter. Endocrine cell Blood vessel Neurotransmitter diffuses across synapse. Secreting cell Secretory vesicle Hormone travels in bloodstream. Target cell specifically binds hormone. Local regulator diffuses through extracellular fluid. Target cell is stimulated. Figure 11.5 Local and long-distance cell signaling by secreted molecules in animals. (a) Paracrine signaling (b) Synaptic signaling (c) Endocrine (hormonal) signaling

Relay molecules in a signal transduction pathway Figure 11.6-3 EXTRACELLULAR FLUID CYTOPLASM Plasma membrane 1 Reception 2 Transduction 3 Response Receptor Activation of cellular response Relay molecules in a signal transduction pathway Figure 11.6 Overview of cell signaling. Signaling molecule

G protein-coupled receptor Plasma membrane Activated receptor Figure 11.7b G protein-coupled receptor Plasma membrane Activated receptor Signaling molecule Inactive enzyme GTP GDP GDP CYTOPLASM G protein (inactive) Enzyme GTP 1 2 GDP Activated enzyme Figure 11.7 Exploring: Cell-Surface Transmembrane Receptors GTP GDP P i 3 Cellular response 4

Signaling molecule (ligand) Ligand-binding site Figure 11.7c Signaling molecule (ligand) Ligand-binding site  helix in the membrane Signaling molecule Tyrosines Tyr Tyr Tyr Tyr Tyr Tyr Tyr Tyr Tyr Tyr Tyr Tyr Tyr Tyr Tyr Tyr Tyr Tyr CYTOPLASM Receptor tyrosine kinase proteins (inactive monomers) Dimer 1 2 Activated relay proteins Figure 11.7 Exploring: Cell-Surface Transmembrane Receptors Cellular response 1 Tyr Tyr P Tyr Tyr P Tyr Tyr P P Tyr Tyr P Tyr Tyr P Tyr Tyr P P Cellular response 2 Tyr Tyr P Tyr Tyr P Tyr Tyr P 6 ATP 6 ADP P Activated tyrosine kinase regions (unphosphorylated dimer) Fully activated receptor tyrosine kinase (phosphorylated dimer) Inactive relay proteins 3 4

Signaling molecule (ligand) Figure 11.7d 1 2 3 Gate closed Ions Gate open Gate closed Signaling molecule (ligand) Plasma membrane Ligand-gated ion channel receptor Cellular response Figure 11.7 Exploring: Cell-Surface Transmembrane Receptors

Hormone (testosterone) EXTRACELLULAR FLUID Figure 11.9-5 Hormone (testosterone) EXTRACELLULAR FLUID Plasma membrane Receptor protein Hormone- receptor complex DNA Figure 11.9 Steroid hormone interacting with an intracellular receptor. mRNA NUCLEUS New protein CYTOPLASM

Activated relay molecule Figure 11.10 Signaling molecule Receptor Activated relay molecule Inactive protein kinase 1 Active protein kinase 1 Inactive protein kinase 2 ATP Phosphorylation cascade ADP Active protein kinase 2 P PP P i Figure 11.10 A phosphorylation cascade. Inactive protein kinase 3 ATP ADP P Active protein kinase 3 PP P i Inactive protein ATP ADP P Active protein Cellular response PP P i

First messenger (signaling molecule such as epinephrine) Figure 11.12 First messenger (signaling molecule such as epinephrine) Adenylyl cyclase G protein G protein-coupled receptor GTP ATP Second messenger cAMP Figure 11.12 cAMP as a second messenger in a G protein signaling pathway. Protein kinase A Cellular responses

G protein-coupled receptor GTP Figure 45.7-2 Epinephrine Adenylyl cyclase G protein G protein-coupled receptor GTP ATP Second messenger cAMP Figure 45.7 Cell-surface hormone receptors trigger signal transduction. Protein kinase A Inhibition of glycogen synthesis Promotion of glycogen breakdown

Glucose 1-phosphate (108 molecules) Figure 11.16 Reception Binding of epinephrine to G protein-coupled receptor (1 molecule) Transduction Inactive G protein Active G protein (102 molecules) Inactive adenylyl cyclase Active adenylyl cyclase (102) ATP Cyclic AMP (104) Inactive protein kinase A Active protein kinase A (104) Figure 11.16 Cytoplasmic response to a signal: the stimulation of glycogen breakdown by epinephrine. Inactive phosphorylase kinase Active phosphorylase kinase (105) Inactive glycogen phosphorylase Active glycogen phosphorylase (106) Response Glycogen Glucose 1-phosphate (108 molecules)