Survival analysis for valproic acid use in adult glioblastoma multiforme: A meta-analysis of individual patient data and a systematic review  Yang Yuan, Wang Xiang, Mao Qing, Liu Yanhui, Luo Jiewen, Mao Yunhe  Seizure - European Journal of Epilepsy  Volume 23, Issue 10, Pages 830-835 (November 2014) DOI: 10.1016/j.seizure.2014.06.015 Copyright © 2014 British Epilepsy Association Terms and Conditions

Fig. 1 Pooled number of patients and percentage of included studies. Seizure - European Journal of Epilepsy 2014 23, 830-835DOI: (10.1016/j.seizure.2014.06.015) Copyright © 2014 British Epilepsy Association Terms and Conditions

Fig. 2 Forrest plot of the studies reporting a primary outcome. Seizure - European Journal of Epilepsy 2014 23, 830-835DOI: (10.1016/j.seizure.2014.06.015) Copyright © 2014 British Epilepsy Association Terms and Conditions

Fig. 3 Sub-group analysis. Seizure - European Journal of Epilepsy 2014 23, 830-835DOI: (10.1016/j.seizure.2014.06.015) Copyright © 2014 British Epilepsy Association Terms and Conditions

Fig. 4 Schematic illustration of VPA and HDAC's influence on cell cycle regulation. ERK: extracellular signal-regulated kinase; HDAC: histone deacetylases. 5-LOX, 5-lipoxygenase; eNOS, endothelial nitric-oxide synthase; JNK, c-jun N-terminal kinase; VPA: valproic acid. Seizure - European Journal of Epilepsy 2014 23, 830-835DOI: (10.1016/j.seizure.2014.06.015) Copyright © 2014 British Epilepsy Association Terms and Conditions