A. Relationship between serum-free thyroxine by dialysis (FT4) ng/dL and log10 TSH in euthyroid, hyperthyroid, hypothyroid, and T4-suppressed euthyroid individuals. Note that for each unit change in T4 there is a logarithmic change in TSH. B. Relationship between FT4 by dialysis and log10 TSH in normal subjects and subjects with various illnesses including primary hypothyroidism, central hypothyroidism and non–levothyroxine-suppressed TSH, levothyroxine-treated congenital hypothyroidism, TSH-secreting tumors, thyroid hormone resistance, nonthyroidal illness, and nonpituitary hyperthyroidism. (Reproduced with permission from Kaptein EM. Clinical applications of free thyroxine determinations. Clin Lab Med. 1993 Sep;13(3):653-672.) Source: The Thyroid Gland, Greenspan's Basic & Clinical Endocrinology, 10e Citation: Gardner DG, Shoback D. Greenspan's Basic & Clinical Endocrinology, 10e; 2017 Available at: http://accessmedicine.mhmedical.com/DownloadImage.aspx?image=/data/books/2178/gardgreen10_ch07_f024b-1.png&sec=166248354&BookID=2178&ChapterSecID=166248172&imagename= Accessed: October 18, 2017 Copyright © 2017 McGraw-Hill Education. All rights reserved