Volume 143, Issue 5, Pages (May 2013)

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Volume 143, Issue 5, Pages 1226-1234 (May 2013) Moderate Glucose Control Is Associated With Increased Mortality Compared With Tight Glucose Control in Critically Ill Patients Without Diabetes  Michael J. Lanspa, MD, Eliotte L. Hirshberg, MD, Gregory D. Phillips, BA, John Holmen, PhD, Gregory Stoddard, MS, James Orme, MD, FCCP  CHEST  Volume 143, Issue 5, Pages 1226-1234 (May 2013) DOI: 10.1378/chest.12-2072 Copyright © 2013 The American College of Chest Physicians Terms and Conditions

Figure 1 eProtocol-insulin algorithm. CHEST 2013 143, 1226-1234DOI: (10.1378/chest.12-2072) Copyright © 2013 The American College of Chest Physicians Terms and Conditions

Figure 2 Selection of glucose targets in eProtocol-insulin throughout the Intermountain Healthcare ICUs from November 2006 to March 2011. CHEST 2013 143, 1226-1234DOI: (10.1378/chest.12-2072) Copyright © 2013 The American College of Chest Physicians Terms and Conditions

Figure 3 Database query method. Apache II = Acute Physiology and Chronic Health Evaluation II. CHEST 2013 143, 1226-1234DOI: (10.1378/chest.12-2072) Copyright © 2013 The American College of Chest Physicians Terms and Conditions

Figure 4 Incidence of moderate hypoglycemia while on eProtocol-insulin, stratified by target glucose. Days on protocol was independently associated with incidence of hypoglycemia in both glucose target groups (P < .01). CHEST 2013 143, 1226-1234DOI: (10.1378/chest.12-2072) Copyright © 2013 The American College of Chest Physicians Terms and Conditions

Figure 5 Cox failure curve for mortality in patients without diabetes. A, Patients without diabetes were more likely to die if they received 90 to 140 mg/dL (dashed line); P = .05. B, Patients with diabetes were more likely to die if they received 80 to 110 mg/dL (solid line); P = .01. CHEST 2013 143, 1226-1234DOI: (10.1378/chest.12-2072) Copyright © 2013 The American College of Chest Physicians Terms and Conditions