Wednesday March 22, 2017 I can: Agenda Catalyst HW: IP: Mutations

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Wednesday March 22, 2017 I can: Agenda Catalyst HW: IP: Mutations explain how mutations affect protein synthesis Agenda (10) Catalyst (30) Alien Encounters! (10) GN: Mutations (15) Kahoot (15) IP: Mutations (5) Exit Ticket Catalyst What is nondisjunction? How does this differ from a mutation? What is the polypeptide made from the DNA sequence TACCAAGTA? HW: IP: Mutations

Mutations A mutation is a change in a DNA sequence. Mutation leads to genetic VARIATION!

How does a substitution affect the overall amino acid sequence? Types of Mutations How does a substitution affect the overall amino acid sequence? Substitution – one base is swapped out for another.

How does an insertion affect the overall amino acid sequence? Types of Mutations How does an insertion affect the overall amino acid sequence? Insertion – an extra base pair(s) is added into a new place in the DNA

How does a deletion affect the overall amino acid sequence? Types of Mutations How does a deletion affect the overall amino acid sequence? Deletion – Base pairs in the sequence are lost or deleted

Types of Mutations A T G A C G T A A A T C G A C G T A A Insertions and deletions are called frame shift mutations. DNA is “read” in 3-base codons in/dels change the reading frame A T G A C G T A A A T C G A C G T A A mutation!