Targeting Aerosol Deposition in Patients With Cystic Fibrosis

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Presentation transcript:

Targeting Aerosol Deposition in Patients With Cystic Fibrosis Laube Beth L. , PhD, Jashnani Rajkumari , PhD, Dalby Richard N. , PhD, Zeitlin Pamela L. , MD, PhD, FCCP CHEST Volume 118, Issue 4, Pages 1069-1076 (October 2000) DOI: 10.1378/chest.118.4.1069 Copyright © 2000 The American College of Chest Physicians Terms and Conditions

Figure 1 I: O ratios after fast and slower inhalations of the two aerosols. The dark bars represent mean values. For the3.68-μm droplets, I: O ratio was unchanged by the two breathing rates. In contrast, I: O ratio was significantly decreased during slowerinspirations of the 1.01-μm droplets, compared to faster inspirations(p = 0.012). CHEST 2000 118, 1069-1076DOI: (10.1378/chest.118.4.1069) Copyright © 2000 The American College of Chest Physicians Terms and Conditions

Figure 2 Skew values after fast or slower inhalations of the two aerosols. The dark bars represent mean values. For the3.68-μm droplets, skew values were unchanged by the two inspiratorymaneuvers. In contrast, skew values were significantly reduced afterslower inspirations of the 1.01-μm droplets, compared to the fasterbreathing maneuvers (p = 0.018). CHEST 2000 118, 1069-1076DOI: (10.1378/chest.118.4.1069) Copyright © 2000 The American College of Chest Physicians Terms and Conditions

Figure 3 Aerosol deposition fraction within the lungs afterfast or slower inspirations of the two aerosols, expressed as apercentage of the amount of radioactivity available for inhalation. Thedark bars represent mean values. Deposition fraction was significantlyincreased during the slow inspiratory maneuvers compared to fasterinspirations for the 3.68-μm droplets (p = 0.038) and for the1.01-μm droplets (p = 0.051). CHEST 2000 118, 1069-1076DOI: (10.1378/chest.118.4.1069) Copyright © 2000 The American College of Chest Physicians Terms and Conditions