Metabolic, Humoral, and Inflammatory Factors

Gaps Better define underlying etiologies and pathophysiology More specific nomenclature Multimodal brain syndrome, TMF: subsyndromes Vascular Neuroexecutive Syndrome Animal models, esp for mood and physical function Mechanisms by which exercise and physical activity affect mood, cognition and physical function

Research Priorities Expand existing basic, epi, and intervention studies to examine all three domains Animal models of TMF and methods for studying mood and physical function in animal models Mechanisms of exercise and physical activity effects

Research Opportunities Effects of function promoting anabolic therapies on cognition and mood in clinical trials Effects of immune modulation on cognition, mood and physical function Human intervention trials Multimodality interventions High risk groups Include all three domains as outcomes