Glioblastoma multiforme (GBM)

Slides:

Advertisements

Similar presentations

Student Case Presentation Nick Paphitis, SMD-06 University of Virginia Health System.

Advertisements

Palisades and tumors. Lung metastatic tumor in brain.

Case Study 62 Kenneth Clark, MD. Question 1 This is a 32-year-old woman with progressive distortion of taste and smell. After seeing her primary care.

CNS Neoplasm Dr. Raid Jastania, FRCPC Assistant Professor, Faculty of Medicine, Umm Alqura University Vice Dean, Faculty of Dentistry.

Case Study 3 Gabrielle Yeaney, M.D.. Question 1 A 7-year-old boy with three month history of nausea, vomiting and headaches. Describe the MRI findings.

Idiopathic Parkinson disease

Chronic glomerulonephritis

Salivary gland in a patient with Sjögren syndrome

Colonic adenocarcinoma metastases to the liver

Central Nervous System

Membranous glomerulonephropathy

Large cell undifferentiated carcinoma of lung

Calcific aortic stenosis

Desmoplastic small round cell tumor

Chronic lymphocytic leukemia (CLL)

Coronal magnetic image (T1) of a large vena caval tumor thrombus (long arrows) in a patient with renal cell carcinoma. Thrombus extends just to entrance.

Tenosynovial giant cell tumor Left low power view shows a lobulated tumor mass with lobules divided by thick collagen fibers (left, low-power view). High.

Invasive breast carcinoma

Peptic ulcers. A, The stomach is opened and laid flat, revealing several large punched-out gastric ulcers. B, A cross-section of a peptic ulcer, illustrating.

(b) Higher magnification shows that principal cells have round central nuclei and pale-staining cytoplasm. Cords of principal cells secreting PTH surround.

Ductal carcinoma in situ (DCIS)

Malignant serous surface epithelial tumor

Radiograph of a giant cell tumor of the thumb

(Figure 1–12c, with permission, from Dr Moise Bendayan, Departments of Pathology and Cell Biology, University of Montreal, Montreal, Canada.) Source: Chapter.

[From Pansky B: Review of Gross Anatomy, 6th ed

Midsagittal section through the brain of a patient with a brain stem tumor. Histologic findings showed the tumor to be an ependymoma. Source: Discussion.

Large cell carcinoma. Note the marked pleomorphism, with no definitive squamoid or glandular differentiation apparent in this section. Most likely, large.

Patterns of ductal carcinoma in situ (DCIS)

Fatty liver. In some cases, the fatty change seen in alcoholics will involve the entire liver (i.e., diffuse fatty liver). Fatty liver can also occur with.

Cellular features of malignancy

Cellular features of malignancy

Renal cell carcinoma, clear cell type

Chronic pancreatitis. A, Note the loss of pancreatic parenchyma and its replacement with fibrosis. Chronic pancreatitis is not an immediately life-threatening.

Chronic myelogenous leukemia (CML)

Liquefactive necrosis of the brain

Meningioma. A, Meningiomas are dural-based neoplasms, frequently located at the cerebral convexities. While most meningiomas do not invade, the tumor can.

Cytomegalovirus (CMV) esophagitis

Renal cell carcinoma, clear cell type

Malignant serous surface epithelial tumor

Focal nodular hyperplasia

The blood-brain barrier. A

Hypertrophic cardiomyopathy

Hypertrophic cardiomyopathy

Invasive breast carcinoma

Follicular lymphoma. A, Follicular lymphoma involves this hilar lymph node. The black material (arrow) represents normal lymphoid parenchyma with anthracotic.

Papillary renal cell carcinoma

Ductal carcinoma in situ (DCIS)

Lymphoma. Malignant lymphomas may occur in the brain, either as primary lesions or as secondary (metastatic) lesion in patients with systemic lymphoma.

Well to moderately differentiated squamous cell carcinoma

Sickle cell anemia. This peripheral blood smear exhibits sickled cells (arrowheads). Sickled cells pass through the vasculature with more difficulty, becoming.

Gastrointestinal stromal tumor

Invasive colonic adenocarcinoma

Hydrocephalus (bottom) versus the normal brain (top)

Asbestos exposure. A, Asbestosis, a chronic restrictive lung disease, is due to asbestos exposure. Note the thick and fibrotic alveolar septae. B, Multiple.

Diabetes mellitus, amyloidosis of the islets and ulcer

Acute lymphoid leukemia (ALL)

Seborrheic keratosis. A, Seborrheic keratosis has a nodular, “stuck-on” gross appearance. B, Microscopically, the tumor is composed of basaloid cells associated.

Clinical and pathologic effects of hepatocellular failure, which commonly results from conditions associated with acute or chronic necrosis of liver cells.

CD3−CD56+ Non-Hodgkin's Lymphomas With an Aggressive Behavior Related to Multidrug Resistance by Bernard Drénou, Thierry Lamy, Laurence Amiot, Olivier.

Eric H. Raabe, Charles G. Eberhart Cancer Cell

Copyright © 2004 The McGraw-Hill Companies, Inc. All rights reserved.

Copyright © 2004 The McGraw-Hill Companies, Inc. All rights reserved.

Patient 1. Patient 1. Axial T2 FLAIR (A) MR image demonstrates abnormal T2 FLAIR signal in the right lateral pons extending into the right trigeminal nerve.

Copyright © 2004 The McGraw-Hill Companies, Inc. All rights reserved.

Copyright © 2004 The McGraw-Hill Companies, Inc. All rights reserved.

Brain Tumor Lab Dr. Mamlook El Maghraby

Copyright © 2004 The McGraw-Hill Companies, Inc. All rights reserved.

Copyright © 2004 The McGraw-Hill Companies, Inc. All rights reserved.

Fig. 4. Pathologic findings of Case 2

A, Recurrent neoplasm in patient 6.

Presentation transcript:

Glioblastoma multiforme (GBM) Glioblastoma multiforme (GBM). A, The right cerebral hemisphere is expanded by an irregularly contoured mass containing areas of necrosis (yellow) and small areas of hemorrhage. Although this lesion appears fairly well demarcated in this gross photograph, GBMs are aggressive astrocytic neoplasms that widely infiltrate the surrounding brain. B, The distinction between the various grades of infiltrating astrocytic neoplasms is based upon four histologic features: nuclear pleomorphism, mitotic figures, endothelial proliferation, and necrosis. GBMs, by definition, contain at least three of these four histologic features. In this section, the necrosis is apparent (star). As is characteristic for GBMs, this tumor has palisading of neoplastic cells at the edge of the necrosis (arrow). Hematoxylin and eosin, 100×. Source: Chapter 11. Neuropathology, Pathology: The Big Picture Citation: Kemp WL, Burns DK, Brown TG. Pathology: The Big Picture; 2008 Available at: https://accessmedicine.mhmedical.com/DownloadImage.aspx?image=/data/books/kemp1/kemp1_c011f028b.png&sec=41570172&BookID=499&ChapterSecID=41568294&imagename= Accessed: October 19, 2017 Copyright © 2017 McGraw-Hill Education. All rights reserved