Figure 1. Joint effect of rs752822 and rs2735839 on prostate cancer aggressiveness and reclassification. (A) Joint effect of rs752822 and rs2735839 on.

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Figure 1. Joint effect of rs752822 and rs2735839 on prostate cancer aggressiveness and reclassification. (A) Joint effect of rs752822 and rs2735839 on risk-stratification of localized GS 7 cancers in phase II. Comparing GS 7 patients with rs752822 CC and rs2735839 GG genotypes, the risks of primary Gleason 4 pattern were significantly increased for GS 7 patients with rs752822 CC+TT and rs2735839 GG genotypes (OR = 1.56, 95% CI = 1.09–2.24, P = 0.016); rs752822 CC and rs2735839 AG+AA (OR = 2.11, 95% CI = 1.30–3.46, P = 0.003); rs752822 CT+TT and rs2735839 AG+AA (OR = 2.71, 95% CI = 1.62–4.51, P = 1.31×10<sup>-4</sup>). The model was adjusted for age, T stage and PSA levels. (B) Joint effect of rs752822 and rs275839 on association with prostate cancer reclassification among localized prostate cancer patients with GS ≤7 in the AS cohort. Comparing to GS 7 patients with rs752822 CC and rs2735839 GG, the risks for prostate cancer reclassification were marginally or significantly increased for GS ≤7 patients with rs752822 CC+TT and rs2735839 GG (HR = 1.39, 95% CI = 0.93–2.08, P = 0.108); rs752822 CC and rs2735839 AG+AA (HR = 1.75, 95% CI = 1.08–2.83, P = 0.024); rs752822 CT+TT and rs2735839 AG+AA (HR = 1.90, 95% CI = 1.13–3.18, P = 0.016). The model was adjusted for age, ethnicity, GS, T stage and PSA levels. From: Genetic variants of the Wnt signaling pathway as predictors of aggressive disease and reclassification in men with early stage prostate cancer on active surveillance Carcinogenesis. 2016;37(10):965-971. doi:10.1093/carcin/bgw082 Carcinogenesis | © The Author 2016. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com.