Anti–IFN-γ autoantibodies are strongly associated with HLA-DR

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Presentation transcript:

Anti–IFN-γ autoantibodies are strongly associated with HLA-DR Anti–IFN-γ autoantibodies are strongly associated with HLA-DR*15:02/16:02 and HLA- DQ*05:01/05:02 across Southeast Asia Cheng-Lung Ku, PhD, Chia-Hao Lin, MS, Su-Wei Chang, PhD, Chen-Chung Chu, PhD, Jasper F.W. Chan, MBBS, Xiao-Fei Kong, MD, PhD, Chen-Hsiang Lee, MD, Emily A. Rosen, BS, Jing-Ya Ding, MS, Wen-I. Lee, MD, PhD, Jacinta Bustamante, MD, PhD, Torsten Witte, MD, Han-Po Shih, MS, Chen-Yen Kuo, MD, Ploenchan Chetchotisakd, MD, Sasisopin Kiertiburanakul, MD, Yupin Suputtamongkol, MD, Kwok-Yung Yuen, MD, Jean-Laurent Casanova, MD, PhD, Steven M. Holland, MD, Rainer Doffinger, PhD, FRCPath, Sarah K. Browne, MD, Chih-Yu Chi, MD, PhD Journal of Allergy and Clinical Immunology Volume 137, Issue 3, Pages 945-948.e8 (March 2016) DOI: 10.1016/j.jaci.2015.09.018 Copyright © 2015 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig E1 Allele frequency variations of HLA-DRB1*15:02, HLA-DRB1*16:02, HLA-DQB1*05:01, and HLA-DRB1*05:02 across worldwide populations. The allele frequencies are presented with different colors, shown as the color bar below the figure. A, HLA-DRB1*15:02. B, HLA-DRB1*16:02. C, HLA-DQB1*05:01. D, HLA-DQB1*05:02. The data were screenshots from the New Allele Frequency Database (http://www.allelefrequencies.net). Journal of Allergy and Clinical Immunology 2016 137, 945-948.e8DOI: (10.1016/j.jaci.2015.09.018) Copyright © 2015 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig E1 Allele frequency variations of HLA-DRB1*15:02, HLA-DRB1*16:02, HLA-DQB1*05:01, and HLA-DRB1*05:02 across worldwide populations. The allele frequencies are presented with different colors, shown as the color bar below the figure. A, HLA-DRB1*15:02. B, HLA-DRB1*16:02. C, HLA-DQB1*05:01. D, HLA-DQB1*05:02. The data were screenshots from the New Allele Frequency Database (http://www.allelefrequencies.net). Journal of Allergy and Clinical Immunology 2016 137, 945-948.e8DOI: (10.1016/j.jaci.2015.09.018) Copyright © 2015 American Academy of Allergy, Asthma & Immunology Terms and Conditions