Allergic reactions to manioc (Manihot esculenta Crantz): Identification of novel allergens with potential involvement in latex-fruit syndrome Keity Souza.

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Allergic reactions to manioc (Manihot esculenta Crantz): Identification of novel allergens with potential involvement in latex-fruit syndrome Keity Souza Santos, PhD, Clovis Eduardo Galvao, MD, PhD, Gabriele Gadermaier, PhD, Virginia Maria Ferreira Resende, BSc, Carlo de Oliveira Martins, BSc, Denise Shimbo Misumi, BSc, Ariana Campos Yang, MD, PhD, Fatima Ferreira, PhD, Mario Sergio Palma, PhD, Jorge Kalil, MD, PhD, Fabio Fernandes Morato Castro, MD, PhD Journal of Allergy and Clinical Immunology Volume 128, Issue 6, Pages 1367-1369 (December 2011) DOI: 10.1016/j.jaci.2011.07.019 Copyright © 2011 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 1 Allergenic reactivity to manioc. A, Clinical features of patients with manioc allergy. %AB, Percentage of activated basophils after stimulation with raw manioc (negative for anti-FcεRI–induced CD63 expression <15%)4; AE, angioedema; BAT, Basophil activation test; CD, contact dermatitis; CU, contact urticaria; F, female; FA, food allergy; ND, not done; SS, Skin symptoms; U, generalized urticaria. A skin prick test wheal area (in square millimeters) of greater than 7 mm2 is considered positive. B, Specific IgE to manioc and starch determined in ELISAs. n.s., Not significant. C, SDS-PAGE (left lane) and immunoblotting (right panel) with sera of patients with manioc allergy (lanes 1-9). F-BA, Fructose-bisphosphate aldolase; ME, manioc extract. Journal of Allergy and Clinical Immunology 2011 128, 1367-1369DOI: (10.1016/j.jaci.2011.07.019) Copyright © 2011 American Academy of Allergy, Asthma & Immunology Terms and Conditions