Study Introduction Welcome To Our Patient Outcome Study about Haemophilia! Next Steps You have been specially invited to participate in a high profile Patient Outcome Study in Haemophilia It is a multi-phased study collecting data from both doctors and their patients (described in more detail on the next page) Study Background These studies are becoming increasingly important as pharmaceutical companies increase focus on patients and regulators look towards real world patient outcomes to support decisions They are also used to ensure the best possible treatment guidelines The data is typically published in peer-review journals, presented at key conferences and thus helps shape the treatment paths for sufferers and improve their lives Examples “Quality of Life of Patients With Alzheimer’s Disease” presented at ISPOR 19th Annual European Congress (2016) “Patient-reported Symptom Burden Among Relapsing-Remitting Multiple Sclerosis (RRMS) vs Secondary Progressive Multiple Sclerosis Patients (SPMS) in Europe” presented at 1st Congress of the European Academy of Neurology Your and your patients feedback will directly lead to improvement in patients treatments and quality of life For more information about M3 Global Research click here

Self Completion Questionnaire* Study Design Phases step by step: Recruitment Qualification Survey Physician Patient Record Forms* Self Completion Questionnaire* Online Paper Patient Pack posted to you by M3 Global Research This recruitment process A 5 minute online qualification survey A 45 minute online survey M3 Global Research will then send you packs of survey materials for patients You complete a 15 - 25 minute patient record form for up to 8 patients as you see them You ask these patients to complete a 20 minute questionnaire and return it to your receptionist for posting to M3 Global Research 5 mins 45 mins 15 - 25 mins 20 mins * These will be linked by three common questions; patients age band, gender and occupation plus a code unique to you. Neither will contain any patient identifiable information to protect the confidentiality of you and your patients.

Self Completion Questionnaire Incentives Physician Survey* £ 100 8 x Patient Record Forms (£100 each)* £ 800 Bonus for 8 Patient Record Forms £ 100 Maximum Total £ 1,000 Recruitment Qualification Survey Physician Patient Record Forms Self Completion Questionnaire Online Paper Patient Pack posted to you by M3 Global Research £100* £100 each* 5 mins 45 mins 15 - 25 mins * A minimum of 3 Patient Record Forms are required to qualify for the Physician Survey incentive 20 mins