The global medical imaging reagents market was valued at $10 The global medical imaging reagents market was valued at $10.3 billion in 2012 and is expected to reach an estimated value of $18.5 billion in 2019.

What we do: Seeing the Invisible Optical probe (IV) Dye Linker Recognition Element Diagnostic and Pre-operative planning Charge Quenching/FRET Wavelength Size Specificity Stability Enzymes Receptors Membrane Affinity-based Dye On Dye On In-vivo Surgical guidance Ion-Channel Receptors Membrane Activity-based Dye On Recognition Element Dye Off Recognition Element Ex-vivo Surgical guidance Substrate-cleavage Tissue sample Protease Hydrolase Transpeptidase Aminopeptidase Dye On Optical probe topical administration

Who we are?

EMI-137 Value in CRC SCREENING

EMI-137 Reduction in Morbidity/Mortality: Colonoscopy Prevent Carcinomas 10% ⅓ 96% adenomas progress to colorectal cancer Early detection & removal of polyps eliminates the possibility they become cancerous. of adults develop ≥ 1 polyps by age 50, this increases with age of colorectal cancers develop from adenomatous polyps over a period of 10-15 years

Standard Colonoscopy Misses Disease 22% miss rate, increases as lesions get smaller. Major reason for CRC in screening population is missed lesions (60%), Poor resection accounts for 20%. An improved detection rate (25%), and lesion classification has been demonstrated

Value in Fluorescent ImagE guided Surgery EMI-137 Value in Fluorescent ImagE guided Surgery

C-Met: Broad expression in Large range of Tumours Cancer type c-Met Expression Poor prognosis Application Optical System Type Bladder 4 Diagnosis & Resection FCFM*, Laproscope Breast Surgical Guidance Open Surgical Cervical Open Surgical, Laparoscope Cholangiocarcinoma FCFM, Surgical Colorectal FCFM, Endoscope, Open Surgical Endometrial 6 FCFM Esophageal FCFM, Endoscope, Laparoscope Gastric H&N Kidney Liver Lung Melanoma Nasopharyngeal Ovarian Pancreatic/Gall Bladder FCFM, Laparoscope, Open Surgical Prostate Open Surgery , Laparoscope Thyroid Open Surgery 10

Pre-operative planning Clinical Studies Agent Indication Report out Funding & Partners CRC Lesion Detection PhIIB in 50+ at risk of CRC patient (1Q-17) EMI-137 Single Pulmonary Nodule Exploratory Clinical study in 20 subjects (1Q-17) EMI-200 Lung Inflammation Phase IIa study in 100 ICU patients (4Q-16) EMI-350 Lung Infection Exploratory Clinical study in 10 ICU patients (3-4Q-16) Diagnostic and Pre-operative planning EMI-400 Lung Fibrosis Exploratory Clinical study 10 Lung Fibrosis patients (1Q-17) EMI-137 Investigator Initiated Studies Exploratory Clinical Studies in cancer surgery patients (4Q-16) EMI-350 Investigator Initiated Studies Exploratory Clinical Studies in infection of hip prosthesis (2Q-17) In-vivo Surgical guidance