Hypophosphatasia Understanding the Disease and Improving Diagnosis
Program Goals
Patient Case Referral for Premature Tooth Loss
Suspicions of HPP
Skeletal Survey
Radiographs
What is HPP?
Mechanism of HPP
Pathophysiology in Bone
Why is Vitamin B6 Elevated? HPP Pathophysiology in the CNS
HPP Common Presentation
Perinatal HPP
Infantile HPP
Childhood HPP
Adult HPP
Odontohypophosphatasia
HPP Disease Burden
Diagnosis of HPP
Diagnosis ALP Levels
Diagnosis Vitamin B6/PLP/PPi/PEA Levels
HPP Treatment
HPP Treatment Challenges
HPP Current Treatment: Asfotase Alfa
Asfotase Alfa Infantile Phase 2 Trial
Infantile Phase 2 Trial Results
Infantile Phase 2 Trial Safety
Patient Case Follow-up
Mortality Rates For Perinatal and Juvenile HPP
Asfotase Alfa Perinatal or Juvenile HPP
Asfotase Alfa Juvenile Trial
Juvenile Trial Results
Juvenile Trial Safety
Closing Comments
Abbreviations