Copyright © 2010 American Medical Association. All rights reserved.

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Copyright © 2010 American Medical Association. All rights reserved. From: Advanced Biological Therapies for Diabetic Foot Ulcers Arch Dermatol. 2010;146(8):857-862. doi:10.1001/archdermatol.2010.164 Figure Legend: Flowchart depicting the disposition of patient records for inclusion in the analysis. *Patients with neuropathic diabetic foot ulcer were identified using an algorithm previously validated: ulcers occurring on the plantar surface of the foot or heel of an individual with diabetes who had adequate arterial perfusion. Bilayered living cell therapy alone indicates Apligraf, Organogenesis Inc, Canton, Massachusetts; becaplermin alone, Regranex, J&J, New Brunswick, New Jersey; platelet releasate alone, Procuren, Cytomedix, Rockville, Maryland; and becaplermin or platelet releasate followed by bilayered living cell therapy, other and Apligraf. Date of download: 10/19/2017 Copyright © 2010 American Medical Association. All rights reserved.

Copyright © 2010 American Medical Association. All rights reserved. From: Advanced Biological Therapies for Diabetic Foot Ulcers Arch Dermatol. 2010;146(8):857-862. doi:10.1001/archdermatol.2010.164 Figure Legend: Kaplan-Meier survival curve demonstrates time to heal after treatment with advanced biological therapies for bilayered living cell therapy alone (Apligraf; Organogenesis Inc, Canton, Massachusetts), becaplermin alone (Regranex; J&J, New Brunswick, New Jersey), platelet releasate alone (Procuren; Cytomedix, Rockville, Maryland), and becaplermin or platelet releasate followed by bilayered living cell therapy (other and Apligraf). Date of download: 10/19/2017 Copyright © 2010 American Medical Association. All rights reserved.

Copyright © 2010 American Medical Association. All rights reserved. From: Advanced Biological Therapies for Diabetic Foot Ulcers Arch Dermatol. 2010;146(8):857-862. doi:10.1001/archdermatol.2010.164 Figure Legend: Ederer survival curve demonstrates time to heal after treatment after adjusting for covariates (age, hypertension, wound area, wound depth, and time from registration to advanced treatment use) with advanced biological therapies for bilayered living cell therapy alone (Apligraf; Organogenesis Inc, Canton, Massachusetts), becaplermin alone (Regranex; J&J, New Brunswick, New Jersey), platelet releasate alone (Procuren; Cytomedix, Rockville, Maryland), and becaplermin or platelet releasate followed by bilayered living cell therapy (other and Apligraf). Date of download: 10/19/2017 Copyright © 2010 American Medical Association. All rights reserved.