Graft smooth muscle cells specifically synthesize increased collagen

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Presentation transcript:

Graft smooth muscle cells specifically synthesize increased collagen Charles L. Mesh, MD, Alana Majors, PhD, Debra Mistele, BS, Linda M. Graham, MD, L.Allen Ehrhart, PhD Journal of Vascular Surgery Volume 22, Issue 2, Pages 142-149 (August 1995) DOI: 10.1016/S0741-5214(95)70108-7 Copyright © 1995 Society for Vascular Surgery and International Society for Cardiovascular Surgery, North American Chapter Terms and Conditions

Fig. 1 Total collagen synthesis in anastomotic graft and adjacent native aortic SMCs. Collagen synthesis is normalized to nanogram of DNA to provide per cell synthetic rate (mean ± standard error; n = 6). Total collagen synthesis was significantly increased in anastomotic graft SMCs (p = 0.03). Journal of Vascular Surgery 1995 22, 142-149DOI: (10.1016/S0741-5214(95)70108-7) Copyright © 1995 Society for Vascular Surgery and International Society for Cardiovascular Surgery, North American Chapter Terms and Conditions

Fig. 2 Total protein synthesis in anastomotic graft and adjacent native aortic SMCs. Total protein synthesis is normalized to nanogram of DNA to provide per cell synthetic rate (mean ± standard error; n = 6). Total protein synthesis is not significantly different in graft anastomotic and adjacent native aortic SMCs. Journal of Vascular Surgery 1995 22, 142-149DOI: (10.1016/S0741-5214(95)70108-7) Copyright © 1995 Society for Vascular Surgery and International Society for Cardiovascular Surgery, North American Chapter Terms and Conditions

Fig. 3 Collagen synthesis as percentage of total protein synthesis in graft anastomotic and adjacent native aortic SMCs. Graft anastomotic SMCs produced significantly more collagen as percentage of total protein synthesis than did adjacent native aortic SMC (mean ± standard error; n = 6; p = 0.001). Journal of Vascular Surgery 1995 22, 142-149DOI: (10.1016/S0741-5214(95)70108-7) Copyright © 1995 Society for Vascular Surgery and International Society for Cardiovascular Surgery, North American Chapter Terms and Conditions

Fig. 4 Northern blot analysis of SMC mRNA from graft anastomotic and adjacent native aortic smooth muscle cells. Probe for type I α-1 procollagen hybridizes to bands at 5.9 and 7.2 kB. Probe for GAPDH hybridizes at 1269 bp. Type I procollagen is increased in graft anastomotic SMC. Journal of Vascular Surgery 1995 22, 142-149DOI: (10.1016/S0741-5214(95)70108-7) Copyright © 1995 Society for Vascular Surgery and International Society for Cardiovascular Surgery, North American Chapter Terms and Conditions