Recombinant allergen fragments as candidate preparations for allergen immunotherapy Thomas Zeiler, MDa, Antti Taivainen, MD, PhDb, Marja Rytkönen, PhDa,

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Presentation transcript:

Recombinant allergen fragments as candidate preparations for allergen immunotherapy Thomas Zeiler, MDa, Antti Taivainen, MD, PhDb, Marja Rytkönen, PhDa, Jaakko Rautiainen, MSca, Henry Karjalainen, PhDa, Rauno Mäntjärvi, MD, PhDa, Leena Tuomisto, MD, PhDc, Tuomas Virtanen, MD, PhDa Journal of Allergy and Clinical Immunology Volume 100, Issue 6, Pages 721-727 (December 1997) DOI: 10.1016/S0091-6749(97)70264-1 Copyright © 1997 Mosby, Inc. Terms and Conditions

FIG. 1 Correlation of anti–rBos d 2 and anti–nBos d 2 IgE titers of cow-asthmatic farmers (r = 0.98, p = 0.003). Regression curve is indicated. Journal of Allergy and Clinical Immunology 1997 100, 721-727DOI: (10.1016/S0091-6749(97)70264-1) Copyright © 1997 Mosby, Inc. Terms and Conditions

FIG. 2 IgE titers against rBos d 2 (gray columns), rBos d 2 (1-131) (open columns), and rBos d 2 (81-172) (black columns) of cow-asthmatic farmers. Letters indicate patients. Journal of Allergy and Clinical Immunology 1997 100, 721-727DOI: (10.1016/S0091-6749(97)70264-1) Copyright © 1997 Mosby, Inc. Terms and Conditions

FIG. 3 Inhibition of the binding of mAb3 to rBos d 2 by nBos d 2 (filled circles), rBos d 2 (open circles), rBos d 2 (1-131) (filled squares), and rBos d 2 (81-172) (open squares). Journal of Allergy and Clinical Immunology 1997 100, 721-727DOI: (10.1016/S0091-6749(97)70264-1) Copyright © 1997 Mosby, Inc. Terms and Conditions

FIG. 4 Cumulative diameters of skin prick test reactions of six cow-asthmatic patients against different preparations at the highest protein concentrations used (nBos d 2 100 μg/ml, recombinant proteins 200 μg/ml). Different patterns in columns indicate different patients. Journal of Allergy and Clinical Immunology 1997 100, 721-727DOI: (10.1016/S0091-6749(97)70264-1) Copyright © 1997 Mosby, Inc. Terms and Conditions