Dimorphic variant of ductal carcinoma in situ of the breast

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Dimorphic variant of ductal carcinoma in situ of the breast Nozomi Ueno, MD, Hajime Kuroda, MD, Yuji Kozuka, MD, Oi Harada, MD, Hiroyuki Kato, MD, Keiichi Kubota, MD, Yasuo Imai, MD Human Pathology: Case Reports Volume 10, Pages 92-95 (November 2017) DOI: 10.1016/j.ehpc.2017.07.006 Copyright © 2017 The Authors Terms and Conditions

Fig. 1 Ultrasound examination showed an irregular hypoechoic mass in the lower outer quadrant of the right breast. Human Pathology: Case Reports 2017 10, 92-95DOI: (10.1016/j.ehpc.2017.07.006) Copyright © 2017 The Authors Terms and Conditions

Fig. 2 Craniocaudal (A) and mediolateral oblique (B) mammogram views of the right breast showing no obvious tumor lesion. Human Pathology: Case Reports 2017 10, 92-95DOI: (10.1016/j.ehpc.2017.07.006) Copyright © 2017 The Authors Terms and Conditions

Fig. 3 Dimorphic DCIS on low-power view. The finding of typical DCIS architecture, such as a cribriform pattern, supports categorization as DCIS. Human Pathology: Case Reports 2017 10, 92-95DOI: (10.1016/j.ehpc.2017.07.006) Copyright © 2017 The Authors Terms and Conditions

Fig. 4 Typical microscopic appearance of two-cell composition of dimorphic DCIS. A cluster of tumor cells with clear cytoplasm (dimorphic cells ⬅) are forming in front of tumor cells with eosinophilic cytoplasm (columnar cells ➩) on a high-power view. Human Pathology: Case Reports 2017 10, 92-95DOI: (10.1016/j.ehpc.2017.07.006) Copyright © 2017 The Authors Terms and Conditions

Fig. 5 The immunohistochemistry for ER (A), p63 (B), E-cadherin (C) and AR (D). Human Pathology: Case Reports 2017 10, 92-95DOI: (10.1016/j.ehpc.2017.07.006) Copyright © 2017 The Authors Terms and Conditions