Blood & tissue protozoa of humans

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Presentation transcript:

Blood & tissue protozoa of humans Trypanosoma Leishmania Malaria

Trypanosoma Species pathogenic to man: T gambiense T rhodesiense T cruzi

Morphology Fusiform, Nucleus in the middle, posterior kinetoplast , anterior free flagellum

Movement Reproduction Nourishment( blood, lymph , C.S.F) Culture: NNN medium.

Life cycle Ulternate existence in vertebrate &invertebrate host.

T. gambiense( mid African sleeping sickness) Vertebrate host : Man Invertebrate host : Tse Tse fly Glossina

Epidemiology West & central Africa Transmission : bite of tse tse fly ( after cyclic development of parasite). Mechanical : During epidemics.

Pathology & symptomatology: Acute stage : blood & lymph Chronic stage : C.S.F. Incubation period:

Acute stage Chronic stage

Trypanosoma rhodesiense ( East African sleeping sickness) Life cycle: Morphology: Pathogenicity : More rapid ,severe, fatal than gambian Tryp.

Trypanosoma cruzi ( American tryponosomiasis) Morphology: Life cycle: Vertebrate host (human , domesticated & wild animals) Invertebrate host: Reduviid bugs .

Epidemiology Pathology & symptoms: In the blood : Trypanosomal form In the cells : Amastigote form. Invade skeletal , cardiac & other muscle fibers

Symptoms The most common are cardiac & GIT symptoms.

Diagnosis Treatment: Nitrofuran.