Neurofibromatosis type 1: a multidisciplinary approach to care

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Presentation transcript:

Neurofibromatosis type 1: a multidisciplinary approach to care Angela C Hirbe, MD, Dr David H Gutmann, MD The Lancet Neurology Volume 13, Issue 8, Pages 834-843 (August 2014) DOI: 10.1016/S1474-4422(14)70063-8 Copyright © 2014 Elsevier Ltd Terms and Conditions

Figure 1 Café-au-lait macule Macule on a 24-year-old woman with neurofibromatosis type 1 who was diagnosed as a young child (measuring tape shown for reference). The Lancet Neurology 2014 13, 834-843DOI: (10.1016/S1474-4422(14)70063-8) Copyright © 2014 Elsevier Ltd Terms and Conditions

Figure 2 Internal plexiform neurofibroma Coronal MRI shows an extensive neurofibroma (asterisk) in an 8-year-old boy with neurofibromatosis type 1. The Lancet Neurology 2014 13, 834-843DOI: (10.1016/S1474-4422(14)70063-8) Copyright © 2014 Elsevier Ltd Terms and Conditions

Figure 3 Skeletal abnormalities in individuals with neurofibromatosis type 1 Plain film radiographs showing: (A) dystrophic scoliosis (asterisk) in an 11-year-old girl; (B) tibial bowing (asterisk) in a 10-month-old baby girl; (C) tibial pseudarthrosis (asterisk) in a 9-month-old baby girl; and (D) tibial pseudarthrosis after insertion of an internal rod (asterisk) in a 9-year-old boy. The Lancet Neurology 2014 13, 834-843DOI: (10.1016/S1474-4422(14)70063-8) Copyright © 2014 Elsevier Ltd Terms and Conditions

Figure 4 Low-grade glial neoplasms (A) MRI showing an optic glioma in the left optic nerve (asterisk) of a 4-year-old boy with neurofibromatosis type 1. (B) MRI showing a brainstem glioma (asterisk) in a 9-year-old boy with neurofibromatosis type 1. The Lancet Neurology 2014 13, 834-843DOI: (10.1016/S1474-4422(14)70063-8) Copyright © 2014 Elsevier Ltd Terms and Conditions

Figure 5 Malignant peripheral nerve-sheath tumours 18F-FDG-PET images showing malignant peripheral nerve-sheath tumours (asterisks) in (A) a 24-year-old woman and (B) a 29-year-old man, both with neurofibromatosis type 1. FDG=fluorodeoxyglucose. The Lancet Neurology 2014 13, 834-843DOI: (10.1016/S1474-4422(14)70063-8) Copyright © 2014 Elsevier Ltd Terms and Conditions