Treatment of Unexplained Chronic Cough Peter Gibson, MBBS, Gang Wang, MD, PhD, Lorcan McGarvey, MD, Anne E. Vertigan, PhD, MBA, BAppSc (SpPath), Kenneth W. Altman, MD, PhD, Surinder S. Birring, MB ChB, MD Todd M. Adams, MD, Kenneth W. Altman, MD, PhD, Alan F. Barker, MD, Surinder S. Birring, MB ChB, MD, Fiona Blackhall, MD, PhD, Donald C. Bolser, PhD, Louis-Philippe Boulet, MD, FCCP, Sidney S. Braman, MD, FCCP, Christopher Brightling, MBBS, PhD, FCCP, Priscilla Callahan-Lyon, MD, Brendan J. Canning, PhD, Anne B. Chang, MBBS, PhD, MPH, Remy Coeytaux, MD, PhD, Terrie Cowley, Paul Davenport, PhD, Rebecca L. Diekemper, MPH, Satoru Ebihara, MD, PhD, Ali A. El Solh, MD, MPH, Patricio Escalante, MD, MSc, FCCP, Anthony Feinstein, MPhil, PhD, Stephen K. Field, MD, Dina Fisher, MD, MSc, Cynthia T. French, PhD, FCCP, Peter Gibson, MBBS, Philip Gold, MD, MACP, FCCP, Michael K. Gould, MD, MS, FCCP, Cameron Grant, MB ChB, PhD, Susan M. Harding, MD, FCCP, Anthony Harnden, MB ChB, MSc, Adam T. Hill, MB ChB, MD, Richard S. Irwin, MD, Master FCCP, Peter J. Kahrilas, MD, Karina A. Keogh, MD, Andrew P. Lane, MD, Kaiser Lim, MD, Mark A. Malesker, PharmD, FCCP, Peter Mazzone, MD, MPH, FCCP, Stuart Mazzone, PhD, FCCP, Douglas C. McCrory, MD, MHS, Lorcan McGarvey, MD, Alex Molasiotis, PhD, MSc, RN, M. Hassan Murad, MD, MPH, Peter Newcombe, PhD, Huong Q. Nguyen, PhD, RN, John Oppenheimer, MD, David Prezant, MD, Tamara Pringsheim, MD, Marcos I. Restrepo, MD, MSc, FCCP, Mark Rosen, MD, Master FCCP, Bruce Rubin, MEngr, MD, MBA, Jay H. Ryu, MD, FCCP, Jaclyn Smith, MB ChB, PhD, Susan M. Tarlo, MBBS, FCCP, Anne E. Vertigan, PhD, MBA, BAppSc (SpPath), Gang Wang, MD, PhD, Miles Weinberger, MD, FCCP, Kelly Weir, MsPath, Renda Soylemez Wiener, MD, MPH Peter Gibson, MBBS, Gang Wang, MD, PhD, Lorcan McGarvey, MD, Anne E. Vertigan, PhD, MBA, BAppSc (SpPath), Kenneth W. Altman, MD, PhD, Surinder S. Birring, MB ChB, MD Todd M. Adams, MD, Kenneth W. Altman, MD, PhD, Alan F. Barker, MD, Surinder S. Birring, MB ChB, MD, Fiona Blackhall, MD, PhD, Donald C. Bolser, PhD, Louis-Philippe Boulet, MD, FCCP, Sidney S. Braman, MD, FCCP, Christopher Brightling, MBBS, PhD, FCCP, Priscilla Callahan-Lyon, MD, Brendan J. Canning, PhD, Anne B. Chang, MBBS, PhD, MPH, Remy Coeytaux, MD, PhD, Terrie Cowley, Paul Davenport, PhD, Rebecca L. Diekemper, MPH, Satoru Ebihara, MD, PhD, Ali A. El Solh, MD, MPH, Patricio Escalante, MD, MSc, FCCP, Anthony Feinstein, MPhil, PhD, Stephen K. Field, MD, Dina Fisher, MD, MSc, Cynthia T. French, PhD, FCCP, Peter Gibson, MBBS, Philip Gold, MD, MACP, FCCP, Michael K. Gould, MD, MS, FCCP, Cameron Grant, MB ChB, PhD, Susan M. Harding, MD, FCCP, Anthony Harnden, MB ChB, MSc, Adam T. Hill, MB ChB, MD, Richard S. Irwin, MD, Master FCCP, Peter J. Kahrilas, MD, Karina A. Keogh, MD, Andrew P. Lane, MD, Kaiser Lim, MD, Mark A. Malesker, PharmD, FCCP, Peter Mazzone, MD, MPH, FCCP, Stuart Mazzone, PhD, FCCP, Douglas C. McCrory, MD, MHS, Lorcan McGarvey, MD, Alex Molasiotis, PhD, MSc, RN, M. Hassan Murad, MD, MPH, Peter Newcombe, PhD, Huong Q. Nguyen, PhD, RN, John Oppenheimer, MD, David Prezant, MD, Tamara Pringsheim, MD, Marcos I. Restrepo, MD, MSc, FCCP, Mark Rosen, MD, Master FCCP, Bruce Rubin, MEngr, MD, MBA, Jay H. Ryu, MD, FCCP, Jaclyn Smith, MB ChB, PhD, Susan M. Tarlo, MBBS, FCCP, Anne E. Vertigan, PhD, MBA, BAppSc (SpPath), Gang Wang, MD, PhD, Miles Weinberger, MD, FCCP, Kelly Weir, MsPath, Renda Soylemez Wiener, MD, MPH  CHEST  Volume 149, Issue 1, Pages 27-44 (January 2016) DOI: 10.1378/chest.15-1496 Copyright © 2016 American College of Chest Physicians Terms and Conditions

Figure 1 A proposed algorithm detailing a management approach to the patient with “difficult-to-treat” cough.5 CHEST 2016 149, 27-44DOI: (10.1378/chest.15-1496) Copyright © 2016 American College of Chest Physicians Terms and Conditions

Figure 2 Systematic review flow diagram. Review Manager (RevMan) computer program. CENTRAL = Cochrane Central Register of Controlled Trials; PICO = population, intervention, comparison, outcome; RCT = randomized controlled trial. CHEST 2016 149, 27-44DOI: (10.1378/chest.15-1496) Copyright © 2016 American College of Chest Physicians Terms and Conditions

Figure 3 A, Quality assessment for included RCTs, overall results. Version 5.2. Copenhagen: The Nordic Cochrane Centre, The Cochrane Collaboration, 2012. B, Quality assessment for included RCTs, individual study results. Review Manager (RevMan) Version 5.2. Computer program. Copenhagen: The Nordic Cochrane Centre, The Cochrane Collaboration, 2012. See Figure 2 legend for expansion of abbreviation. CHEST 2016 149, 27-44DOI: (10.1378/chest.15-1496) Copyright © 2016 American College of Chest Physicians Terms and Conditions