Stem Cells in Wound Healing: The Future of Regenerative Medicine

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Presentation transcript:

Stem Cells in Wound Healing: The Future of Regenerative Medicine Stem Cells in Wound Healing: The Future of Regenerative Medicine? A Mini-Review Gerontology 2016;62:216-225 - DOI:10.1159/000381877 Fig. 1. Stem cell sources. Progenitor cells for wound therapies can be obtained from various sources, each with its particular advantages and disadvantages for clinical translation. © 2015 S. Karger AG, Basel

Stem Cells in Wound Healing: The Future of Regenerative Medicine Stem Cells in Wound Healing: The Future of Regenerative Medicine? A Mini-Review Gerontology 2016;62:216-225 - DOI:10.1159/000381877 Fig. 2. Characteristics of different progenitor cell populations. a ASCs are routinely harvested from lipoaspirate and are multipotent with the capacity to differentiate down all four mesodermal lineages: fat, bone, cartilage, and muscle. After isolation they can be used therapeutically with and without ex vivo expansion. b Adult somatic cells can be reprogrammed as iPSCs with the same differentiation capacity as ESCs. With all their benefits and only a few of their limitations, iPSCs have significant advantages over ESCs, particularly with regard to clinical translation. © 2015 S. Karger AG, Basel

Stem Cells in Wound Healing: The Future of Regenerative Medicine Stem Cells in Wound Healing: The Future of Regenerative Medicine? A Mini-Review Gerontology 2016;62:216-225 - DOI:10.1159/000381877 Fig. 3. Challenges of the aged wound microenvironment. Several important characteristics set aged wounds apart from their younger counterparts. In advanced age, a progressive impairment of native stem cells and neovascularization have been identified as potential underlying causes of poor wound healing. © 2015 S. Karger AG, Basel

Stem Cells in Wound Healing: The Future of Regenerative Medicine Stem Cells in Wound Healing: The Future of Regenerative Medicine? A Mini-Review Gerontology 2016;62:216-225 - DOI:10.1159/000381877 Fig. 4. Influence of advanced age on progenitor cell subpopulation dynamics. Biological aging manifests in a disruption of cellular subpopulation ecology. © 2015 S. Karger AG, Basel

Stem Cells in Wound Healing: The Future of Regenerative Medicine Stem Cells in Wound Healing: The Future of Regenerative Medicine? A Mini-Review Gerontology 2016;62:216-225 - DOI:10.1159/000381877 Fig. 5. Stem cell delivery approaches for cutaneous wounds. A prerequisite for successful progenitor cell therapy for cutaneous wounds is an adequate delivery mechanism. Several different applications strategies with particular advantages and disadvantages are currently in preclinical and clinical evaluation, with bioscaffold-based approaches appearing to be the most promising. © 2015 S. Karger AG, Basel